Early- and advanced non-enzymatic glycation in diabetic vascular complications: the search for therapeutics

• Published in: Amino acids Vol. 42; no. 4; pp. 1193 - 1204
• Main Authors: Schalkwijk, Casper G., Miyata, Toshio
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.04.2012; Springer Nature B.V
• Subjects: Advanced glycosylation end products; Amino acids; Analytical Chemistry; Animals; Biochemical Engineering; Biochemistry; Biological; Biomedical and Life Sciences; Cardiovascular diseases; Damage; Diabetes; Diabetes mellitus; Diabetic Angiopathies - drug therapy; Diabetic Angiopathies - enzymology; Diabetic Angiopathies - metabolism; Glycation End Products, Advanced - antagonists & inhibitors; Glycation End Products, Advanced - metabolism; Glycosylation - drug effects; Humans; Inhibitors; Life Sciences; Morbidity; Mortality; Neurobiology; Proteins; Proteins - metabolism; Proteomics; Review; Review Article; Searching; Vascular diseases; Amadori-albumin; Non-enzymatic glycation; AGEs; Diabetes; Vascular complications
• ISSN: 0939-4451; 1438-2199; 1438-2199
• DOI: 10.1007/s00726-010-0779-9

Cardiovascular disease is a common complication of diabetes and the leading cause of death among people with diabetes. Because of the huge premature morbidity and mortality associated with diabetes, prevention of vascular complications is a key issue. Although the exact mechanism by which vascular damage occurs in diabetes in not fully understood, numerous studies support the hypothesis of a causal relationship of non-enzymatic glycation with vascular complications. In this review, data which point to an important role of Amadori-modified glycated proteins and advanced glycation endproducts in vascular disease are surveyed. Because of the potential role of early- and advanced non-enzymatic glycation in vascular complications, we also described recent developments of pharmacological inhibitors that inhibit the formation of these glycated products or the biological consequences of glycation and thereby retard the development of vascular complications in diabetes.