Distorted time perception in patients with neurocognitive impairment

• Published in: Heliyon Vol. 10; no. 16; p. e36002
• Main Authors: Kim, Yerim, Bae, Jong Seok, Kim, Yeo Jin, Lee, Ju-Hun, Park, Soo-Hyun, Lee, Minwoo, Lee, Sang-Hwa, Kim, Chulho
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 30.08.2024; Elsevier
• Subjects: Alzheimer disease; Alzheimer's disease; cognition; cognitive disorders; Neurocognitive impairment; Neuropsychological assessments; Parkinson disease; pathophysiology; Time perception; Vascular dementia; Neurocognitive impairment; Vascular dementia; Alzheimer's disease; Neuropsychological assessments; Time perception
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2024.e36002

Time perception is known to be distorted in patients with neuropsychiatric disorders. Therefore, this study aims to investigate the correlation between cognitive decline and time distortion by examining time perception in participants with neurocognitive impairment (Alzheimer's disease [AD], vascular dementia [VD], and Parkinson's disease dementia [PDD]) compared to those with subjective cognitive impairment (SCI). Overall, 569 participants with cognitive decline complaints between 2013 and 2022 were investigated. Participants were subjected to a verbal estimation task, time production task, time comparison task, and neuropsychological assessments. Time perception abilities were distorted in patients with neurocognitive impairment compared to those with SCI. Despite similar educational backgrounds, the vascular cognitive impairment (VCI)/VD group demonstrated the lowest MMSE scores (22.4 ± 4.2, p-value <0.001) and larger time-estimation errors. Patients with VCI/VD significantly underestimated time in the 35-s (19.6 ± 12.6s) and 60-s (28.7 ± 19.9s) tasks. In the time production task, patients with VCI/VD produced shorter times in their 15-s (12.7 ± 4.3; p-value = 0.001), 30-s (23.6 ± 8.3; p value < 0.001), and 60-s (43.8 ± 18.9; p-value <0.001) trials. In the time comparison task, the VCI/VD group had significantly fewer correct answers than that in the SCI groups (6.0 ± 1.3 vs. 7.1 ± 0.9, p-value <0.001). Correlation analysis revealed that multiple cognitive functions are involved in the time perception tasks. Patients with VCI/VD had the poorest time perception. These findings may provide a modest contribution to understanding the underlying pathophysiology and psychological connections related to temporal abilities in time perception.