Associations of genetic polymorphisms of SAA1 with cerebral infarction

• Published in: Lipids in health and disease Vol. 12; no. 1; p. 130
• Main Authors: Zhang, Li-Jun, Yuan, Bin, Li, He-Hua, Tao, Sheng-Bo, Yan, Hai-Qing, Chang, Li, Zhao, Jian-Hua
• Format: Journal Article
• Language: English
• Published: London BioMed Central 29.08.2013; BioMed Central Ltd
• Subjects: Age; Aged; Alleles; Analysis; Apolipoproteins; Asian Continental Ancestry Group; Atherosclerosis; Autoimmune diseases; Biomedical and Life Sciences; Care and treatment; Case-Control Studies; Cerebral Infarction - ethnology; Cerebral Infarction - genetics; Cerebral ischemia; Clinical Nutrition; Disease; Female; Gene Expression; Gene Frequency; Genetic aspects; Genetic Markers; Genetic polymorphisms; Genetic Predisposition to Disease; Genotype & phenotype; Glycoproteins; Health aspects; Heart attacks; Hospitals; Humans; Life Sciences; Lipidology; Lipids; Lipoproteins; Male; Medical Biochemistry; Medical research; Medicine, Experimental; Middle Aged; Neurology; Plasma; Polymorphism, Single Nucleotide; Population; Serum Amyloid A Protein - genetics; Single nucleotide polymorphisms; Studies; China; Serum amyloid A; Cerebral infarction; Genetic polymorphisms
• ISSN: 1476-511X; 1476-511X
• DOI: 10.1186/1476-511X-12-130

Background Serum amyloid A protein (SAA) is both an inflammatory factor and an apolipoprotein. However, the relation between genetic polymorphisms of SAA and cerebral infarction (CI) remains unclear. Methods and results The previously reported 4 Single Nucleotide Polymorphisms (rs12218, rs4638289, rs7131332, and rs11603089) of SAA1 gene were genotyped by TaqMan method in a case–control study including 287 cerebral infarction patients and 376 control subjects. We found rs12218 CC genotype and rs7131332 AA genotype were more frequent among CI patients than among controls (9.76% versus 3.19%, P = 0.001; 32.75% versus 24.20%; p = 0.017; respectively). After adjustment of confounding factors such as sex, age, smoking, drinking, hypertension, diabetes, and lipids profile, the difference remained significant in rs12218 (P < 0.01, OR = 2.106, 95% CI: 1.811–7.121). Conclusion Genetic polymorphism of SAA1 may be a genetic maker of cerebral infarction in Chinese.