Association of moderate and severe hypertriglyceridemia with obesity, diabetes mellitus and vascular disease in the Spanish working population: Results of the ICARIA study

• Published in: Atherosclerosis Vol. 207; no. 2; pp. 573 - 578
• Main Authors: Valdivielso, Pedro, Sánchez-Chaparro, Miguel Ángel, Calvo-Bonacho, Eva, Cabrera-Sierra, Martha, Sainz-Gutiérrez, Juan Carlos, Fernández-Labandera, Carlos, Fernández-Meseguer, Ana, Quevedo-Aguado, Luis, Moraga, Montserrat Ruiz, Gálvez-Moraleda, Adolfo, González-Quintela, Arturo, Roman-Garcia, Javier
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01.12.2009; Elsevier
• Subjects: Adult; Associated diseases and complications; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular; Cardiovascular disease; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; Cardiovascular Diseases - prevention & control; Cross-Sectional Studies; Diabetes; Diabetes Complications - epidemiology; Diabetes Complications - prevention & control; Diabetes. Impaired glucose tolerance; Employment; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Humans; Hypertriglyceridemia; Hypertriglyceridemia - epidemiology; Hypertriglyceridemia - etiology; Hypertriglyceridemia - prevention & control; Logistic Models; Male; Medical sciences; Metabolic syndrome; Middle Aged; Obesity; Obesity - complications; Obesity - epidemiology; Obesity - therapy; Occupational Health; Prevalence; Risk Assessment; Risk Factors; Severity of Illness Index; Spain - epidemiology; Vascular disease; Spain; Vascular disease; Obesity; Cardiovascular disease; Diabetes; Metabolic syndrome; Hypertriglyceridemia; Endocrinopathy; Diabetes mellitus; Nutrition disorder; Metabolic diseases; Lipids; Hyperlipoproteinemia; Lipoprotein; Triglyceride; Enzymopathy; Atherosclerosis; Spanish; Dyslipemia; Nutritional status
• ISSN: 0021-9150; 1879-1484; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2009.05.024

To study the prevalence, risk factors, and vascular disease associated with moderate and severe hypertriglyceridemia in an active working population. Cross-sectional study of 594,701 workers from all Spanish geographical areas, occupation sectors, ages, and sexes who underwent a yearly routine checkup. Data collected from participants included age, sex, anthropometric measurements, vascular risk factors, lipidic profile and basic biochemical analysis, from a fasting blood sample. A cardiovascular risk assessment was performed. The study population included 428,334 males and 166,367 females, mean age 36 ± 10 years. A total of 95,673 (16%) workers had mild hypertriglyceridemia (HTg) (Tg 150–399 mg/dL), 7,081 (1.1%) had moderate HTg (400–999 mg/dL), and 224 (0.03%) had severe HTg (≥1000 mg/dL). Of workers with hypertriglyceridemia, 90% were male. Age, obesity, type 1 and 2 diabetes, alcohol consumption, and vascular disease were associated with hypertriglyceridemia. Cardiovascular risk gradually increased for each HTg category. Amongst risk factors, the major independent predictor of mild-HTg was obesity (OR 2.42, CI 95% 2.37–2.48), whereas diabetes was a predictor of moderate HTg (OR 3.64, CI 95% 3.17–4.18) and severe HTg (OR 7.35, CI 95% 4.27–12.66). In multivariate analyses, HTg was gradually associated with vascular disease, even after adjusting for other risk factors. In this working population, preventive programs for HTg and associated vascular disease should consider obesity–diabetes control as its first objective.