N‐Acetylcysteine improves microcirculatory flow during smoking: New effects of an old drug with possible benefits for smokers

Background: Cigarette smoking provokes marked acute changes in the microcirculatory vasculature, including a reduced blood flow velocity. in accordance with the hypothesis that the reduced blood flow is due to an imbalance between pro‐oxidants and oxidants, we recently showed that most of the reduct...

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Published inClinical cardiology (Mahwah, N.J.) Vol. 24; no. 7; pp. 511 - 515
Main Authors Lu, Qing, Björkhem, Ingemar, Xiu, R.‐J., Henrksson, Peter, Freyschuss, Anna
Format Journal Article
LanguageEnglish
Published New York Wiley Periodicals, Inc 01.07.2001
Wiley
Subjects
Acetylcysteine - pharmacology
Adult
antioxidant
Antioxidants - pharmacology
Biological and medical sciences
Blood Flow Velocity - drug effects
capillary blood flow velocity
Case-Control Studies
Clinical Investigation
Clinical Investigations
endothelium
Female
General and cellular metabolism. Vitamins
Humans
Male
Medical sciences
microcirculation
Microcirculation - drug effects
Microscopic Angioscopy
N‐acetylcysteine
Pharmacology. Drug treatments
smoking
Smoking - physiopathology
Human
Microcirculation
Toxicology
Thiol
Tobacco smoking
Acetylcysteine
Circulatory velocity
Blood capillary
Antioxidant
Biological activity
Endothelium
Online AccessGet full text
ISSN0160-9289
1932-8737
DOI10.1002/clc.4960240719

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Abstract Background: Cigarette smoking provokes marked acute changes in the microcirculatory vasculature, including a reduced blood flow velocity. in accordance with the hypothesis that the reduced blood flow is due to an imbalance between pro‐oxidants and oxidants, we recently showed that most of the reduction could be reversed by a high dose of vitamin C. Hypothesis: in the present work we tested the hypothesis that N‐acetylcysteine, a mucolyticum and an antioxidant, may have an effect on the smoking‐induced changes observed by vital capillary microscopy of the nailfold. Methods: in all, 37 healthy volunteers of both genders and with varied smoking habits were treated with N‐acetylcysteine 200 mg t.i.d. for 2 weeks. in vivo investigation of the microcirculation by capillaroscopy was performed before and after treatment. Results: Treatment with N‐acetylcysteine significantly reduced the smoking‐induced relative decrease in capillary blood flow velocity in a group of volunteers with varied smoking habits (p=0.0016). The preventive effect was clearly significant in smokers (p=0.003). Conclusion: Treatment with N‐acetylcysteine has a positive impact on microcirculatory flow during smoking, particularly in habitual smokers.
AbstractList Cigarette smoking provokes marked acute changes in the microcirculatory vasculature, including a reduced blood flow velocity. In accordance with the hypothesis that the reduced blood flow is due to an imbalance between pro-oxidants and oxidants, we recently showed that most of the reduction could be reversed by a high dose of vitamin C. In the present work we tested the hypothesis that N-acetylcysteine, a mucolyticum and an antioxidant, may have an effect on the smoking-induced changes observed by vital capillary microscopy of the nailfold. In all, 37 healthy volunteers of both genders and with varied smoking habits were treated with N-acetylcysteine 200 mg t.i.d. for 2 weeks. In vivo investigation of the microcirculation by capillaroscopy was performed before and after treatment. Treatment with N-acetylcysteine significantly reduced the smoking-induced relative decrease in capillary blood flow velocity in a group of volunteers with varied smoking habits (p = 0.0016). The preventive effect was clearly significant in smokers (p = 0.003). Treatment with N-acetylcysteine has a positive impact on microcirculatory flow during smoking, particularly in habitual smokers.
Background: Cigarette smoking provokes marked acute changes in the microcirculatory vasculature, including a reduced blood flow velocity. in accordance with the hypothesis that the reduced blood flow is due to an imbalance between pro‐oxidants and oxidants, we recently showed that most of the reduction could be reversed by a high dose of vitamin C. Hypothesis: in the present work we tested the hypothesis that N‐acetylcysteine, a mucolyticum and an antioxidant, may have an effect on the smoking‐induced changes observed by vital capillary microscopy of the nailfold. Methods: in all, 37 healthy volunteers of both genders and with varied smoking habits were treated with N‐acetylcysteine 200 mg t.i.d. for 2 weeks. in vivo investigation of the microcirculation by capillaroscopy was performed before and after treatment. Results: Treatment with N‐acetylcysteine significantly reduced the smoking‐induced relative decrease in capillary blood flow velocity in a group of volunteers with varied smoking habits (p=0.0016). The preventive effect was clearly significant in smokers (p=0.003). Conclusion: Treatment with N‐acetylcysteine has a positive impact on microcirculatory flow during smoking, particularly in habitual smokers.
Background: Cigarette smoking provokes marked acute changes in the microcirculatory vasculature, including a reduced blood flow velocity. in accordance with the hypothesis that the reduced blood flow is due to an imbalance between pro‐oxidants and oxidants, we recently showed that most of the reduction could be reversed by a high dose of vitamin C. Hypothesis: in the present work we tested the hypothesis that N‐acetylcysteine, a mucolyticum and an antioxidant, may have an effect on the smoking‐induced changes observed by vital capillary microscopy of the nailfold. Methods: in all, 37 healthy volunteers of both genders and with varied smoking habits were treated with N‐acetylcysteine 200 mg t.i.d. for 2 weeks. in vivo investigation of the microcirculation by capillaroscopy was performed before and after treatment. Results: Treatment with N‐acetylcysteine significantly reduced the smoking‐induced relative decrease in capillary blood flow velocity in a group of volunteers with varied smoking habits (p=0.0016). The preventive effect was clearly significant in smokers (p=0.003). Conclusion: Treatment with N‐acetylcysteine has a positive impact on microcirculatory flow during smoking, particularly in habitual smokers.
Background: Cigarette smoking provokes marked acute changes in the microcirculatory vasculature, including a reduced blood flow velocity. in accordance with the hypothesis that the reduced blood flow is due to an imbalance between pro-oxidants and oxidants, we recently showed that most of the reduction could be reversed by a high dose of vitamin C. Hypothesis: in the present work we tested the hypothesis that N-acetylcysteine, a mucolyticum and an antioxidant, may have an effect on the smoking-induced changes observed by vital capillary microscopy of the nailfold. Methods: in all, 37 healthy volunteers of both genders and with varied smoking habits were treated with N-acetylcysteine 200 mg t.i.d. for 2 weeks. in vivo investigation of the microcirculation by capillaroscopy was performed before and after treatment. Results: Treatment with N-acetylcysteine significantly reduced the smoking-induced relative decrease in capillary blood flow velocity in a group of volunteers with varied smoking habits (p=0.0016). The preventive effect was clearly significant in smokers (p=0.003). Conclusion: Treatment with N-acetylcysteine has a positive impact on microcirculatory flow during smoking, particularly in habitual smokers.
Cigarette smoking provokes marked acute changes in the microcirculatory vasculature, including a reduced blood flow velocity. In accordance with the hypothesis that the reduced blood flow is due to an imbalance between pro-oxidants and oxidants, we recently showed that most of the reduction could be reversed by a high dose of vitamin C.BACKGROUNDCigarette smoking provokes marked acute changes in the microcirculatory vasculature, including a reduced blood flow velocity. In accordance with the hypothesis that the reduced blood flow is due to an imbalance between pro-oxidants and oxidants, we recently showed that most of the reduction could be reversed by a high dose of vitamin C.In the present work we tested the hypothesis that N-acetylcysteine, a mucolyticum and an antioxidant, may have an effect on the smoking-induced changes observed by vital capillary microscopy of the nailfold.HYPOTHESISIn the present work we tested the hypothesis that N-acetylcysteine, a mucolyticum and an antioxidant, may have an effect on the smoking-induced changes observed by vital capillary microscopy of the nailfold.In all, 37 healthy volunteers of both genders and with varied smoking habits were treated with N-acetylcysteine 200 mg t.i.d. for 2 weeks. In vivo investigation of the microcirculation by capillaroscopy was performed before and after treatment.METHODSIn all, 37 healthy volunteers of both genders and with varied smoking habits were treated with N-acetylcysteine 200 mg t.i.d. for 2 weeks. In vivo investigation of the microcirculation by capillaroscopy was performed before and after treatment.Treatment with N-acetylcysteine significantly reduced the smoking-induced relative decrease in capillary blood flow velocity in a group of volunteers with varied smoking habits (p = 0.0016). The preventive effect was clearly significant in smokers (p = 0.003).RESULTSTreatment with N-acetylcysteine significantly reduced the smoking-induced relative decrease in capillary blood flow velocity in a group of volunteers with varied smoking habits (p = 0.0016). The preventive effect was clearly significant in smokers (p = 0.003).Treatment with N-acetylcysteine has a positive impact on microcirculatory flow during smoking, particularly in habitual smokers.CONCLUSIONTreatment with N-acetylcysteine has a positive impact on microcirculatory flow during smoking, particularly in habitual smokers.
Author Xiu, R.‐J.
Björkhem, Ingemar
Freyschuss, Anna
Lu, Qing
Henrksson, Peter
AuthorAffiliation 1 Division of Clinical Chemistry and Department of Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
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Microcirculation
Toxicology
Thiol
Tobacco smoking
Acetylcysteine
Circulatory velocity
Blood capillary
Antioxidant
Biological activity
Endothelium
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Snippet Background: Cigarette smoking provokes marked acute changes in the microcirculatory vasculature, including a reduced blood flow velocity. in accordance with...
Background: Cigarette smoking provokes marked acute changes in the microcirculatory vasculature, including a reduced blood flow velocity. in accordance with...
Cigarette smoking provokes marked acute changes in the microcirculatory vasculature, including a reduced blood flow velocity. In accordance with the hypothesis...
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StartPage 511
SubjectTerms Acetylcysteine - pharmacology
Adult
antioxidant
Antioxidants - pharmacology
Biological and medical sciences
Blood Flow Velocity - drug effects
capillary blood flow velocity
Case-Control Studies
Clinical Investigation
Clinical Investigations
endothelium
Female
General and cellular metabolism. Vitamins
Humans
Male
Medical sciences
microcirculation
Microcirculation - drug effects
Microscopic Angioscopy
N‐acetylcysteine
Pharmacology. Drug treatments
smoking
Smoking - physiopathology
Title N‐Acetylcysteine improves microcirculatory flow during smoking: New effects of an old drug with possible benefits for smokers
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fclc.4960240719
https://www.ncbi.nlm.nih.gov/pubmed/11444642
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https://www.proquest.com/docview/744611074
https://pubmed.ncbi.nlm.nih.gov/PMC6654995
http://kipublications.ki.se/Default.aspx?queryparsed=id:1938160
Volume 24
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