Foveal Avascular Zone in Normal Tension Glaucoma Measured by Optical Coherence Tomography Angiography

• Published in: BioMed research international Vol. 2017; no. 2017; pp. 1 - 7
• Main Authors: Golubovic, Mladjan, Jovanovic, Svetlana, Sefic Kasumovic, Sanja, Radenkovic, Marija, Jaksic, Vesna, Zlatanovic, Gordana, Zlatanovic, Marko, Kocaturk, Tolga, Dayanir, Volkan, Zivkovic, Maja, Jovanovic, Predrag
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2017; Hindawi; John Wiley & Sons, Inc
• Subjects: Aged; Angiography; Coherence; Density; Diagnosis; Female; Fluorescein Angiography - methods; Glaucoma; Humans; Low Tension Glaucoma - diagnosis; Low Tension Glaucoma - diagnostic imaging; Low Tension Glaucoma - pathology; Macula Lutea - diagnostic imaging; Macula Lutea - pathology; Male; Middle Aged; Observer Variation; Optical Coherence Tomography; Patients; Retinal Vessels - diagnostic imaging; Retinal Vessels - pathology; Tension; Tomography; Tomography, Optical Coherence - methods; Serbia
• ISSN: 2314-6133; 2314-6141; 2314-6141
• DOI: 10.1155/2017/3079141

Aim. To measure diameter of foveal avascular zone (FAZ), FAZ area, and vessel density using Optical Coherence Tomography Angiography (OCT-A) in patients with normal tension glaucoma (NTG) and to establish the possible role of OCT-A in diagnosis and follow-up of patients with NTG. Methods. Twenty-one eyes of 21 patients with NTG and 30 eyes of 30 healthy subjects underwent complete ophthalmic examination as well as OCT-A on ZEISS AngioPlex. 3×3 macula scans were used to measure vertical, horizontal, and maximum diameter of FAZ by two graders. Mean values and interobserver variability were analyzed. Image J was used for analysis of FAZ area and vessel density. Results. Mean vertical diameter (t=5.58, p<0.001), horizontal diameter (t=3.59, p<0.001), maximum diameter (t=5.94, p<0.001), and FAZ area (t=5.76, p<0.001) were statistically significantly enlarged in the NTG group compared to those in the control group. Vessel density (t=-5.80, p<0.001) was statistically significantly decreased in the NTG group compared to that in the control group. Conclusion. OCT-A could have an important role in the future in diagnosis of patients with NTG. In patients with NTG, there is larger FAZ area, while the vessel density is reduced in comparison to the control group.