Psychiatric morbidity and X-chromosomal origin in a Klinefelter sample
The presence of an additional X-chromosome in Klinefelter patients provides an opportunity to study the influence of this chromosome on psychiatric disorders. Previous studies have reported an excess of Klinefelter patients in psychiatric patient groups. We report an increased prevalence of psychiat...
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| Published in | Schizophrenia research Vol. 93; no. 1; pp. 399 - 402 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier B.V
01.07.2007
Elsevier Science |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0920-9964 |
| DOI | 10.1016/j.schres.2007.03.015 |
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| Abstract | The presence of an additional X-chromosome in Klinefelter patients provides an opportunity to study the influence of this chromosome on psychiatric disorders. Previous studies have reported an excess of Klinefelter patients in psychiatric patient groups. We report an increased prevalence of psychiatric disorders including psychotic disorders in a sample of Klinefelter patients but could not find evidence of an effect of the parental origin of the extra X-chromosome on the psychiatric phenotype. Nevertheless, these findings provide further support for the role of the X-chromosome in the susceptibility to psychiatric disorders in general and psychotic disorders in particular. |
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| AbstractList | AbstractThe presence of an additional X-chromosome in Klinefelter patients provides an opportunity to study the influence of this chromosome on psychiatric disorders. Previous studies have reported an excess of Klinefelter patients in psychiatric patient groups. We report an increased prevalence of psychiatric disorders including psychotic disorders in a sample of Klinefelter patients but could not find evidence of an effect of the parental origin of the extra X-chromosome on the psychiatric phenotype. Nevertheless, these findings provide further support for the role of the X-chromosome in the susceptibility to psychiatric disorders in general and psychotic disorders in particular. The presence of an additional X-chromosome in Klinefelter patients provides an opportunity to study the influence of this chromosome on psychiatric disorders. Previous studies have reported an excess of Klinefelter patients in psychiatric patient groups. We report an increased prevalence of psychiatric disorders including psychotic disorders in a sample of Klinefelter patients but could not find evidence of an effect of the parental origin of the extra X-chromosome on the psychiatric phenotype. Nevertheless, these findings provide further support for the role of the X-chromosome in the susceptibility to psychiatric disorders in general and psychotic disorders in particular.The presence of an additional X-chromosome in Klinefelter patients provides an opportunity to study the influence of this chromosome on psychiatric disorders. Previous studies have reported an excess of Klinefelter patients in psychiatric patient groups. We report an increased prevalence of psychiatric disorders including psychotic disorders in a sample of Klinefelter patients but could not find evidence of an effect of the parental origin of the extra X-chromosome on the psychiatric phenotype. Nevertheless, these findings provide further support for the role of the X-chromosome in the susceptibility to psychiatric disorders in general and psychotic disorders in particular. The presence of an additional X-chromosome in Klinefelter patients provides an opportunity to study the influence of this chromosome on psychiatric disorders. Previous studies have reported an excess of Klinefelter patients in psychiatric patient groups. We report an increased prevalence of psychiatric disorders including psychotic disorders in a sample of Klinefelter patients but could not find evidence of an effect of the parental origin of the extra X-chromosome on the psychiatric phenotype. Nevertheless, these findings provide further support for the role of the X-chromosome in the susceptibility to psychiatric disorders in general and psychotic disorders in particular. |
| Author | van Rijn, Sophie Giltay, Jacques C. Sommer, Iris E. Swaab, Hanna de Vette, Marjolein H.T. Boks, Marco P.M. Kahn, René S. |
| Author_xml | – sequence: 1 givenname: Marco P.M. surname: Boks fullname: Boks, Marco P.M. email: mboks@umcutrecht.nl organization: Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, Utrecht, The Netherlands – sequence: 2 givenname: Marjolein H.T. surname: de Vette fullname: de Vette, Marjolein H.T. organization: Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, Utrecht, The Netherlands – sequence: 3 givenname: Iris E. surname: Sommer fullname: Sommer, Iris E. organization: Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, Utrecht, The Netherlands – sequence: 4 givenname: Sophie surname: van Rijn fullname: van Rijn, Sophie organization: Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, Utrecht, The Netherlands – sequence: 5 givenname: Jacques C. surname: Giltay fullname: Giltay, Jacques C. organization: Department Biomedical Genetics, University Medical Centre Utrecht, The Netherlands – sequence: 6 givenname: Hanna surname: Swaab fullname: Swaab, Hanna organization: Department of Clinical Child and Adolescent Studies, Leiden University, Leiden, The Netherlands – sequence: 7 givenname: René S. surname: Kahn fullname: Kahn, René S. organization: Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, Utrecht, The Netherlands |
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| Keywords | Psychosis X-chromosome Prevalence Klinefelter Chromosomal aberration Endocrinopathy Social environment Human Klinefelter syndrome Mental health Aneuploidy Sexual differentiation disorder Supernumerary X chromosome Genetic determinism Epidemiology Symptomatology Malformation Mental disorder Genetics Male genital diseases Public health |
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| SubjectTerms | Adult Adult and adolescent clinical studies Biological and medical sciences Chromosome aberrations Chromosomes, Human, X - genetics Comorbidity Cross-Sectional Studies Genetic Predisposition to Disease - genetics Humans Klinefelter Klinefelter Syndrome - diagnosis Klinefelter Syndrome - epidemiology Klinefelter Syndrome - genetics Klinefelter Syndrome - psychology Male Medical genetics Medical sciences Mental Disorders - diagnosis Mental Disorders - epidemiology Mental Disorders - genetics Middle Aged Miscellaneous Phenotype Prevalence Psychiatric/Mental Health Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychosis Psychotic Disorders - diagnosis Psychotic Disorders - genetics Psychotic Disorders - psychology Schizophrenia - diagnosis Schizophrenia - genetics Schizophrenic Psychology Sex Chromosome Aberrations X-chromosome |
| Title | Psychiatric morbidity and X-chromosomal origin in a Klinefelter sample |
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