Psychiatric morbidity and X-chromosomal origin in a Klinefelter sample

• Published in: Schizophrenia research Vol. 93; no. 1; pp. 399 - 402
• Main Authors: Boks, Marco P.M., de Vette, Marjolein H.T., Sommer, Iris E., van Rijn, Sophie, Giltay, Jacques C., Swaab, Hanna, Kahn, René S.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.07.2007; Elsevier Science
• Subjects: Adult; Adult and adolescent clinical studies; Biological and medical sciences; Chromosome aberrations; Chromosomes, Human, X - genetics; Comorbidity; Cross-Sectional Studies; Genetic Predisposition to Disease - genetics; Humans; Klinefelter; Klinefelter Syndrome - diagnosis; Klinefelter Syndrome - epidemiology; Klinefelter Syndrome - genetics; Klinefelter Syndrome - psychology; Male; Medical genetics; Medical sciences; Mental Disorders - diagnosis; Mental Disorders - epidemiology; Mental Disorders - genetics; Middle Aged; Miscellaneous; Phenotype; Prevalence; Psychiatric/Mental Health; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychosis; Psychotic Disorders - diagnosis; Psychotic Disorders - genetics; Psychotic Disorders - psychology; Schizophrenia - diagnosis; Schizophrenia - genetics; Schizophrenic Psychology; Sex Chromosome Aberrations; X-chromosome; Netherlands; Europe; Psychosis; X-chromosome; Prevalence; Klinefelter; Chromosomal aberration; Endocrinopathy; Social environment; Human; Klinefelter syndrome; Mental health; Aneuploidy; Sexual differentiation disorder; Supernumerary X chromosome; Genetic determinism; Epidemiology; Symptomatology; Malformation; Mental disorder; Genetics; Male genital diseases; Public health
• ISSN: 0920-9964
• DOI: 10.1016/j.schres.2007.03.015

The presence of an additional X-chromosome in Klinefelter patients provides an opportunity to study the influence of this chromosome on psychiatric disorders. Previous studies have reported an excess of Klinefelter patients in psychiatric patient groups. We report an increased prevalence of psychiatric disorders including psychotic disorders in a sample of Klinefelter patients but could not find evidence of an effect of the parental origin of the extra X-chromosome on the psychiatric phenotype. Nevertheless, these findings provide further support for the role of the X-chromosome in the susceptibility to psychiatric disorders in general and psychotic disorders in particular.