Associations of SAA1 gene polymorphism with Lipid lelvels and osteoporosis in Chinese women

• Published in: Lipids in health and disease Vol. 12; no. 1; p. 39
• Main Authors: Feng, Zheng-Ping, Li, Xiao-Yu, Jiang, Rong, Deng, Hua-Cong, Yang, Mei, Zhou, Qin, Que, Wen-Jun, Du, Jia
• Format: Journal Article
• Language: English
• Published: London BioMed Central 22.03.2013; BioMed Central Ltd
• Subjects: Biomedical and Life Sciences; Bone Density - genetics; China; Cholesterol, HDL - blood; Cholesterol, HDL - genetics; Clinical Nutrition; Development and progression; Female; Genetic aspects; Genetic Association Studies; Genetic polymorphisms; Health aspects; Humans; Life Sciences; Lipidology; Lipids; Lipids - blood; Lipids - genetics; Low density lipoproteins; Medical Biochemistry; Middle Aged; Osteoporosis; Osteoporosis, Postmenopausal - blood; Osteoporosis, Postmenopausal - genetics; Osteoporosis, Postmenopausal - pathology; Polymorphism, Single Nucleotide; Public health; Risk Factors; Serum Amyloid A Protein - genetics; Women; China; SAA1; Osteoporosis; Genetic polymorphism
• ISSN: 1476-511X; 1476-511X
• DOI: 10.1186/1476-511X-12-39

Background The development of osteoporosis is associated with several risk factors, such as genetic polymorphisms and enviromental factors. This study assessed the correlation between SAA1 gene rs12218 polymorphism and HDL-C lelvels and osteoporosis in a population of Chinese women. Methods A total of 387 postmenopausal female patients who were diagnosed with osteoporosis (case group) based on bone mineral density measurements via dual-energy x-ray absorptiometry and 307 females with no osteoporosis (control group) were included in this study. Correlations between SAA1 gene rs12218 polymorphism and osteoporosis and HDL-C level were investigated through the identification of SAA1 gene rs12218 polymorphism genotypes using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The TT genotype of rs12218 was more frequently in osteoporosis patients than in control subjects (P <0.001). And the rs12218 was found to be associated with plasma TG, HDL-C, LDL-C, and BMD levels in osteoporosis patients (P<0.05). Conclusions The present results indicate that both osteoporosis and lipids levels are associated with the TT genotype of rs12218 in the human SAA1 gene.