Correlation between skin, bone, and cerebrospinal fluid layer thickness and optical coefficients measured by multidistance frequency-domain near-infrared spectroscopy in term and preterm infants

• Published in: Journal of biomedical optics Vol. 19; no. 1; p. 017004
• Main Authors: Demel, Anja, Feilke, Katharina, Wolf, Martin, Poets, Christian F, Franz, Axel R
• Format: Journal Article
• Language: English
• Published: United States Society of Photo-Optical Instrumentation Engineers 01.01.2014
• Subjects: Algorithms; Bone and Bones - anatomy & histology; Bones; Cerebrospinal fluid; Cerebrospinal Fluid - chemistry; Cerebrovascular Circulation; Correlation; Correlation analysis; Female; Hemodynamics; Hemoglobins - analysis; Humans; Infant; Infant, Newborn; Infant, Premature; Infants; Intensive Care, Neonatal; Light; Male; Monitoring, Physiologic - methods; Neonatology - instrumentation; Optics and Photonics; Oxygen - analysis; Oxygen - blood; Oxygenation; Oxyhemoglobins - analysis; Photons; Scattering, Radiation; Skin - anatomy & histology; Skull - diagnostic imaging; Spectroscopy; Spectroscopy, Near-Infrared; Ultrasonography; Ultrasound; near-infrared spectroscopy; preterm infant; layer thickness; regional cerebral oxygen saturation
• ISSN: 1083-3668; 1560-2281; 1560-2281
• DOI: 10.1117/1.JBO.19.1.017004

Near-infrared spectroscopy (NIRS) is increasingly used in neonatal intensive care. We investigated the impact of skin, bone, and cerebrospinal fluid (CSF) layer thickness in term and preterm infants on absorption-(μa) and/or reduced scattering coefficients (μs′) measured by multidistance frequency-domain (FD)-NIRS. Transcranial ultrasound was performed to measure the layer thicknesses. Correlations were only statistically significant for μa at 692 nm with bone thickness and μs′ at 834 nm with skin thickness. There is no evidence that skin, bone, or CSF thickness have an important effect on μa and μs′. Layer thicknesses of skin, bone, and CSF in the range studied do not seem to affect cerebral oxygenation measurements by multidistance FD-NIRS significantly.