Fracture toughness of heat cured denture base acrylic resin modified with Chlorhexidine and Fluconazole as bioactive compounds

• Published in: Journal of dentistry Vol. 42; no. 2; pp. 180 - 184
• Main Authors: Al-Haddad, Alaa, Vahid Roudsari, Reza, Satterthwaite, Julian D.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2014; Elsevier Limited
• Subjects: Acrylic resin; Acrylic resins; Algorithms; Anti-Infective Agents, Local - chemistry; Antifungal Agents - chemistry; Bioactive compound; Chlorhexidine; Chlorhexidine - chemistry; Dental Materials - chemistry; Dental Stress Analysis - instrumentation; Dentistry; Denture; Denture Bases; Dentures; Fluconazole; Fluconazole - chemistry; Fracture toughness; Heat; Hot Temperature; Humans; Materials Testing; Mechanical properties; Pliability; Polymethyl Methacrylate - chemistry; Polymethyl methacrylates; Prosthetics; Samples; Statistical analysis; Stress, Mechanical; Surface Properties; United Kingdom > UK; Acrylic resin; Bioactive compound; Chlorhexidine; Fluconazole; Denture; Fracture toughness
• ISSN: 0300-5712; 1879-176X; 1879-176X
• DOI: 10.1016/j.jdent.2013.11.007

This study investigated the impact of incorporating Chlorhexidine and Fluconazole as bioactive compounds on the fracture toughness of conventional heat cured denture base acrylic resin material (PMMA). 30 single edge-notched (SEN) samples were prepared and divided into three groups. 10% (mass) Chlorhexidine and 10% (mass) Diflucan powder (4.5% mass Fluconazole) were added to heat cured PMMA respectively to create the two study groups. A third group of conventional heat cured PMMA was prepared as the control group. Fracture toughness (3-point bending test) was carried out for each sample and critical force (Fc) and critical stress intensity factor (KIC) values measured. Data were subject to parametric statistical analysis using one-way ANOVA and Post hoc Bonferroni test (p=0.05). Fluconazole had no significant effect on the fracture toughness of the PMMA while Chlorhexidine significantly reduced the KIC and therefore affected the fracture toughness. When considering addition of a bioactive material to PMMA acrylic, Chlorhexidine will result in reduced fracture toughness of the acrylic base while Fluconazole has no effect.