Intracerebral mechanisms explaining the impact of incidental feedback on mood state and risky choice

• Published in: eLife Vol. 11
• Main Authors: Cecchi, Romane, Vinckier, Fabien, Hammer, Jiri, Marusic, Petr, Nica, Anca, Rheims, Sylvain, Trebuchon, Agnès, Barbeau, Emmanuel J, Denuelle, Marie, Maillard, Louis, Minotti, Lorella, Kahane, Philippe, Pessiglione, Mathias, Bastin, Julien
• Format: Journal Article
• Language: English
• Published: eLife Science Publications, Ltd 13.07.2022; eLife Sciences Publication; eLife Sciences Publications, Ltd; eLife Sciences Publications Ltd
• Subjects: Analysis; choice; Computational and Systems Biology; Human acts; Human behavior; iEEG; Life Sciences; mood; Neurons and Cognition; Neuroscience; Psychology and behavior; computational biology; systems biology; mood; neuroscience; choice; human; iEEG
• ISSN: 2050-084X; 2050-084X
• DOI: 10.7554/eLife.72440

Identifying factors whose fluctuations are associated with choice inconsistency is a major issue for rational decision theory. Here, we investigated the neuro-computational mechanisms through which mood fluctuations may bias human choice behavior. Intracerebral EEG data were collected in a large group of subjects (n=30) while they were performing interleaved quiz and choice tasks that were designed to examine how a series of unrelated feedbacks affect decisions between safe and risky options. Neural baseline activity preceding choice onset was confronted first to mood level, estimated by a computational model integrating the feedbacks received in the quiz task, and then to the weighting of option attributes, in a computational model predicting risk attitude in the choice task. Results showed that (1) elevated broadband gamma activity (BGA) in the ventromedial prefrontal cortex (vmPFC) and dorsal anterior insula (daIns) was respectively signaling periods of high and low mood, (2) increased vmPFC and daIns BGA respectively promoted and tempered risk taking by overweighting gain vs. loss prospects. Thus, incidental feedbacks induce brain states that correspond to different moods and bias the evaluation of risky options. More generally, these findings might explain why people experiencing positive (or negative) outcome in some part of their life tend to expect success (or failure) in any other.