HYR, an extracellular module involved in cellular adhesion and related to the immunoglobulin-like fold

• Published in: Protein science Vol. 9; no. 7; pp. 1382 - 1390
• Main Authors: CALLEBAUT, ISABELLE, GILGÈS, DELPHINE, VIGON, ISABELLE, MORNON, JEAN-PAUL
• Format: Journal Article
• Language: English
• Published: Bristol Cambridge University Press 01.07.2000; Cold Spring Harbor Laboratory Press; Wiley
• Subjects: adhesion; Amino Acid Sequence; Bacterial Proteins - chemistry; Biochemistry, Molecular Biology; Cell Adhesion - physiology; complement control protein; Extracellular Matrix Proteins - chemistry; Extracellular Matrix Proteins - metabolism; fibronectin type III; Fibronectins - chemistry; FOR THE RECORD; hyalin; Hyalin - chemistry; hydrophobic cluster analysis; Immunoglobulins - chemistry; iterative database search; Life Sciences; Molecular Sequence Data; polycystic kidney disease; Protein Folding; Proteins - chemistry; Repetitive Sequences, Amino Acid; Sequence Homology, Amino Acid; Structural Biology; TRPP Cation Channels; fibronectin type III; polycystic kidney disease; adhesion; iterative database search; complement control protein; hydrophobic cluster analysis; hyalin
• ISSN: 0961-8368; 1469-896X
• DOI: 10.1110/ps.9.7.1382

Domains belonging to the immunoglobulin-like fold are responsible for a wide variety of molecular recognition processes. Here we describe a new family of domains, the HYR family, which is predicted to belong to this fold, and which appears to be involved in cellular adhesion. HYR domains were identified in several eukaryotic proteins, often associated with Complement Control Protein (CCP) modules or arranged in multiple copies. Our analysis provides a sequence and structural basis for understanding the role of these domains in interaction mechanisms and leads to further characterization of heretofore undescribed repeated domains with similar folds found in several bacterial proteins involved in enzymatic activities (some chitinases) or in cell surface adhesion (streptococcal C-alpha antigen).