Interval-value Based Particle Swarm Optimization algorithm for cancer-type specific gene selection and sample classification

• Published in: Genomics data Vol. 5; no. C; pp. 46 - 50
• Main Authors: Ramyachitra, D., Sofia, M., Manikandan, P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2015; Elsevier
• Subjects: data collection; gene expression; Gene selection; genes; Interval-value based Particle Swarm Optimization classification; Interval-value classification; Microarray; microarray technology; neoplasms; Particle swarm optimization; Regular; support vector machines; surveys; Tissue sample classification; Interval-value classification; Gene selection; Microarray; Tissue sample classification; Particle swarm optimization; Interval-value based Particle Swarm Optimization classification
• ISSN: 2213-5960; 2213-5960
• DOI: 10.1016/j.gdata.2015.04.027

Microarray technology allows simultaneous measurement of the expression levels of thousands of genes within a biological tissue sample. The fundamental power of microarrays lies within the ability to conduct parallel surveys of gene expression using microarray data. The classification of tissue samples based on gene expression data is an important problem in medical diagnosis of diseases such as cancer. In gene expression data, the number of genes is usually very high compared to the number of data samples. Thus the difficulty that lies with data are of high dimensionality and the sample size is small. This research work addresses the problem by classifying resultant dataset using the existing algorithms such as Support Vector Machine (SVM), K-nearest neighbor (KNN), Interval Valued Classification (IVC) and the improvised Interval Value based Particle Swarm Optimization (IVPSO) algorithm. Thus the results show that the IVPSO algorithm outperformed compared with other algorithms under several performance evaluation functions.