Antiosteoporotic Activity of Anthraquinones from Morinda officinalis on Osteoblasts and Osteoclasts
Bioactivity-guided fractionation led to the successful isolation of antiosteoporotic components, i.e. physicion (1), rubiadin-1-methyl ether (2), 2-hydroxy-1-methoxy- anthraquinone (3), 1,2-dihydroxy-3-methylanthraquinone (4), 1,3,8-trihydroxy-2-methoxy- anthraquinone (5), 2-hydroxymethyl-3-hydroxya...
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| Published in | Molecules (Basel, Switzerland) Vol. 14; no. 1; pp. 573 - 583 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
MDPI AG
23.01.2009
Molecular Diversity Preservation International |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1420-3049 1420-3049 |
| DOI | 10.3390/molecules14010573 |
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| Abstract | Bioactivity-guided fractionation led to the successful isolation of antiosteoporotic components, i.e. physicion (1), rubiadin-1-methyl ether (2), 2-hydroxy-1-methoxy- anthraquinone (3), 1,2-dihydroxy-3-methylanthraquinone (4), 1,3,8-trihydroxy-2-methoxy- anthraquinone (5), 2-hydroxymethyl-3-hydroxyanthraquinone (6), 2-methoxyanthraquinone (7) and scopoletin (8) from an ethanolic extract of the roots of Morinda officinalis. Compounds 4-8 are isolated for the first time from M. officinalis. Among them, compounds 2 and 3 promoted osteoblast proliferation, while compounds 4, 5 increased osteoblast ALP activity. All of the isolated compounds inhibited osteoclast TRAP activity and bone resorption, and the inhibitory effects on osteoclastic bone resorption of compounds 1 and 5 were stronger than that of other compounds. Taken together, antiosteoporotic activity of M. officinalis and its anthraquinones suggest therapeutic potential against osteoporosis. |
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| AbstractList | Bioactivity-guided fractionation led to the successful isolation of antiosteoporotic components, i.e. physicion (1), rubiadin-1-methyl ether (2), 2-hydroxy-1-methoxy- anthraquinone (3), 1,2-dihydroxy-3-methylanthraquinone (4), 1,3,8-trihydroxy-2-methoxy- anthraquinone (5), 2-hydroxymethyl-3-hydroxyanthraquinone (6), 2-methoxyanthraquinone (7) and scopoletin (8) from an ethanolic extract of the roots of Morinda officinalis. Compounds 4-8 are isolated for the first time from M. officinalis. Among them, compounds 2 and 3 promoted osteoblast proliferation, while compounds 4, 5 increased osteoblast ALP activity. All of the isolated compounds inhibited osteoclast TRAP activity and bone resorption, and the inhibitory effects on osteoclastic bone resorption of compounds 1 and 5 were stronger than that of other compounds. Taken together, antiosteoporotic activity of M. officinalis and its anthraquinones suggest therapeutic potential against osteoporosis. Bioactivity-guided fractionation led to the successful isolation of antiosteoporotic components, i.e. physicion ( 1 ), rubiadin-1-methyl ether ( 2 ), 2-hydroxy-1-methoxy- anthraquinone ( 3 ), 1,2-dihydroxy-3-methylanthraquinone ( 4 ), 1,3,8-trihydroxy-2-methoxy- anthraquinone ( 5 ), 2-hydroxymethyl-3-hydroxyanthraquinone ( 6 ), 2-methoxyanthraquinone ( 7 ) and scopoletin ( 8 ) from an ethanolic extract of the roots of Morinda officinalis . Compounds 4-8 are isolated for the first time from M. officinalis. Among them, compounds 2 and 3 promoted osteoblast proliferation, while compounds 4, 5 increased osteoblast ALP activity. All of the isolated compounds inhibited osteoclast TRAP activity and bone resorption, and the inhibitory effects on osteoclastic bone resorption of compounds 1 and 5 were stronger than that of other compounds. Taken together, antiosteoporotic activity of M. officinalis and its anthraquinones suggest therapeutic potential against osteoporosis. Bioactivity-guided fractionation led to the successful isolation of antiosteoporotic components, i.e. physicion (1), rubiadin-1-methyl ether (2), 2-hydroxy-1-methoxy- anthraquinone (3), 1,2-dihydroxy-3-methylanthraquinone (4), 1,3,8-trihydroxy-2-methoxy- anthraquinone (5), 2-hydroxymethyl-3-hydroxyanthraquinone (6), 2-methoxyanthraquinone (7) and scopoletin (8) from an ethanolic extract of the roots of Morinda officinalis. Compounds 4-8 are isolated for the first time from M. officinalis. Among them, compounds 2 and 3 promoted osteoblast proliferation, while compounds 4, 5 increased osteoblast ALP activity. All of the isolated compounds inhibited osteoclast TRAP activity and bone resorption, and the inhibitory effects on osteoclastic bone resorption of compounds 1 and 5 were stronger than that of other compounds. Taken together, antiosteoporotic activity of M. officinalis and its anthraquinones suggest therapeutic potential against osteoporosis.Bioactivity-guided fractionation led to the successful isolation of antiosteoporotic components, i.e. physicion (1), rubiadin-1-methyl ether (2), 2-hydroxy-1-methoxy- anthraquinone (3), 1,2-dihydroxy-3-methylanthraquinone (4), 1,3,8-trihydroxy-2-methoxy- anthraquinone (5), 2-hydroxymethyl-3-hydroxyanthraquinone (6), 2-methoxyanthraquinone (7) and scopoletin (8) from an ethanolic extract of the roots of Morinda officinalis. Compounds 4-8 are isolated for the first time from M. officinalis. Among them, compounds 2 and 3 promoted osteoblast proliferation, while compounds 4, 5 increased osteoblast ALP activity. All of the isolated compounds inhibited osteoclast TRAP activity and bone resorption, and the inhibitory effects on osteoclastic bone resorption of compounds 1 and 5 were stronger than that of other compounds. Taken together, antiosteoporotic activity of M. officinalis and its anthraquinones suggest therapeutic potential against osteoporosis. |
| Author | Zhang, Qiao-Yan Sun, Lian-Na Qin, Lu-Ping Wu, Yan-Bin Han, Ting Jiao, Lei Zheng, Cheng-Jian Wu, Jin-Zhong |
| AuthorAffiliation | 1 Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350108, P.R. China; E-mail: wxsq1@163.com (Y-B. W.) 2 Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, P.R. China 3 Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350108, P.R. China |
| AuthorAffiliation_xml | – name: 2 Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, P.R. China – name: 1 Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350108, P.R. China; E-mail: wxsq1@163.com (Y-B. W.) – name: 3 Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350108, P.R. China |
| Author_xml | – sequence: 1 givenname: Yan-Bin surname: Wu fullname: Wu, Yan-Bin – sequence: 2 givenname: Cheng-Jian surname: Zheng fullname: Zheng, Cheng-Jian – sequence: 3 givenname: Lu-Ping surname: Qin fullname: Qin, Lu-Ping – sequence: 4 givenname: Lian-Na surname: Sun fullname: Sun, Lian-Na – sequence: 5 givenname: Ting surname: Han fullname: Han, Ting – sequence: 6 givenname: Lei surname: Jiao fullname: Jiao, Lei – sequence: 7 givenname: Qiao-Yan surname: Zhang fullname: Zhang, Qiao-Yan – sequence: 8 givenname: Jin-Zhong surname: Wu fullname: Wu, Jin-Zhong |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19169204$$D View this record in MEDLINE/PubMed |
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| Snippet | Bioactivity-guided fractionation led to the successful isolation of antiosteoporotic components, i.e. physicion (1), rubiadin-1-methyl ether (2),... Bioactivity-guided fractionation led to the successful isolation of antiosteoporotic components, i.e. physicion ( 1 ), rubiadin-1-methyl ether ( 2 ),... |
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| SubjectTerms | Alkaline Phosphatase - metabolism Animals Anthraquinones Anthraquinones - chemistry Anthraquinones - pharmacology Anthraquinones - therapeutic use Bone Density Conservation Agents - chemistry Bone Density Conservation Agents - pharmacology Bone Density Conservation Agents - therapeutic use Bone Resorption - drug therapy Cell Proliferation - drug effects Cells, Cultured Fractionation Molecular Structure Morinda - chemistry Morinda officinalis Osteoblast Osteoblasts - cytology Osteoblasts - drug effects Osteoclast Osteoclasts - cytology Osteoclasts - drug effects Osteoporosis Pharmacy Phosphatase Rats Rats, Wistar Traditional Chinese medicine |
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| Title | Antiosteoporotic Activity of Anthraquinones from Morinda officinalis on Osteoblasts and Osteoclasts |
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