Enhanced antibacterial properties of orthopedic implants by titanium nanotube surface modification: a review of current techniques

Prosthesis-associated infections are one of the main causes of implant failure; thus it is important to enhance the long-term antibacterial ability of orthopedic implants. Titanium dioxide nanotubes (TNTs) are biomaterials with good physicochemical properties and biocompatibility. Owing to their inh...

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Bibliographic Details
Published inInternational journal of nanomedicine Vol. 14; pp. 7217 - 7236
Main Authors Li, Yuehong, Yang, Yue, Li, Ruiyan, Tang, Xiongfeng, Guo, Deming, Qing, Yun'an, Qin, Yanguo
Format Journal Article
LanguageEnglish
Published Dove Medical Press Limited 01.09.2019
Dove
Dove Medical Press
Subjects
Analysis
Antibacterial agents
antibacterial property
Biological products
drug delivery
Drug delivery systems
Health aspects
Infection
Nanotubes
orthopedic implant
Production processes
Prostheses and implants
Review
surface modification
Titanium dioxide
titanium dioxide nanotube
TNT (Trinitrotoluene)
Toxicity
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ISSN1178-2013
1176-9114
1178-2013
DOI10.2147/IJN.S216175

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Summary:Prosthesis-associated infections are one of the main causes of implant failure; thus it is important to enhance the long-term antibacterial ability of orthopedic implants. Titanium dioxide nanotubes (TNTs) are biomaterials with good physicochemical properties and biocompatibility. Owing to their inherent antibacterial and drug-loading ability, the antibacterial application of TNTs has received increasing attention. In this review, the process of TNT anodizing fabrication is summarized. Also, the mechanism and the influencing factors of the antibacterial property of bare TNTs are explored. Furthermore, different antibacterial strategies for carrying drugs, as well as modifications to prolong the antibacterial effect and reduce drug-related toxicity are discussed. In addition, antibacterial systems based on TNTs that can automatically respond to infection are introduced. Finally, the currently faced problems are reviewed and potential solutions are proposed. This review provides new insight on TNT fabrication and summarizes the most advanced antibacterial strategies involving TNTs for the enhancement of long-term antibacterial ability and reduction of toxicity. Keywords: antibacterial property, drug delivery, titanium dioxide nanotube, orthopedic implant, surface modification
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ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S216175