Boosting of Cellular Immunity against Mycobacterium tuberculosis and Modulation of Skin Cytokine Responses in Healthy Human Volunteers by Mycobacterium bovis BCG Substrain Moreau Rio de Janeiro Oral Vaccine

• Published in: Infection and Immunity Vol. 74; no. 4; pp. 2449 - 2452
• Main Authors: Cosgrove, Catherine A, Castello-Branco, Luiz R. R, Hussell, Tracy, Sexton, Amy, Giemza, Rafaela, Phillips, Richard, Williams, Andrew, Griffin, George E, Dougan, Gordon, Lewis, David J. M
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.04.2006
• Subjects: administration & dosage; Administration, Oral; Adult; adults; Applied microbiology; Bacterial diseases; Biological and medical sciences; biosynthesis; cell-mediated immunity; Cells, Cultured; childhood; Cytokines; Cytokines - biosynthesis; Female; Fundamental and applied biological sciences. Psychology; Human bacterial diseases; Humans; Immunity, Cellular; immunization; Immunization, Secondary; immunology; Infectious diseases; Injections, Intradermal; interferon-gamma; Male; Medical sciences; metabolism; Microbial Immunity and Vaccines; Microbiology; Mycobacterium bovis; Mycobacterium bovis - immunology; Mycobacterium bovis BCG; Mycobacterium tuberculosis; Mycobacterium tuberculosis - immunology; prevention & control; Skin; Skin - immunology; Skin - metabolism; Skin - microbiology; Tuberculin; Tuberculin - immunology; tuberculosis; Tuberculosis - immunology; Tuberculosis - prevention & control; Tuberculosis and atypical mycobacterial infections; Tuberculosis Vaccines; Tuberculosis Vaccines - administration & dosage; Tuberculosis Vaccines - immunology; vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Human; Microbiology; Mycobacterium bovis; BCG; Cytokine; Cellular immunity; Vaccine; Mycobacterial infection; Infection; Tuberculosis; Mycobacterium tuberculosis; Mycobacteriales; Bacteriosis; Mycobacteriaceae; Bacteria; Actinomycetes; Skin
• ISSN: 0019-9567; 1098-5522
• DOI: 10.1128/IAI.74.4.2449-2452.2006

Oral immunization of healthy adults with 10⁷ CFU BCG Moreau Rio de Janeiro was well tolerated and significantly boosted gamma interferon responses to purified protein derivative, Ag85, and MPB70 from previous childhood intradermal BCG immunization. Oral BCG offers the possibility of a needle-free tuberculosis vaccine and of boosting the protective immunity from intradermal tuberculosis vaccines.