Mechanisms controlling arrangements and movements of nuclei in pseudostratified epithelia

During development, cells undergo complex rearrangements that contribute to the final tissue architecture. A characteristic arrangement found in rapidly expanding, highly proliferative tissues is pseudostratified epithelium, which features notably elongated cells with varied nuclear positions along...

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Published in	Trends in cell biology Vol. 23; no. 3; pp. 141 - 150
Main Authors	Lee, Hyun O., Norden, Caren
Format	Journal Article
Language	English
Published	England Elsevier Ltd 01.03.2013
Subjects	Actins - metabolism Anemone - cytology Anemone - physiology Animals Cell Differentiation Cell Division cell nucleus Cell Nucleus - physiology Cell Nucleus - ultrastructure cytoskeleton Drosophila melanogaster - cytology Drosophila melanogaster - physiology Dyneins - metabolism Epithelial Cells - cytology Epithelial Cells - physiology Epithelial Cells - ultrastructure epithelium Epithelium - physiology Epithelium - ultrastructure Humans interkinetic nuclear migration Kinesin - metabolism Microtubules - metabolism Microtubules - ultrastructure Movement nuclear movements Pathology polarity proliferation pseudostratified epithelia Rodentia - physiology skin diseases pseudostratified epithelia proliferation cytoskeleton nuclear movements interkinetic nuclear migration polarity
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ISSN	0962-8924 1879-3088 1879-3088
DOI	10.1016/j.tcb.2012.11.001

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Summary:	During development, cells undergo complex rearrangements that contribute to the final tissue architecture. A characteristic arrangement found in rapidly expanding, highly proliferative tissues is pseudostratified epithelium, which features notably elongated cells with varied nuclear positions along the cell axis. Although anomalies in its structure are implicated in diseases like microcephaly, how pseudostratification is formed and maintained remains elusive. In this review, we focus on a typical feature of pseudostratified epithelia called interkinetic nuclear migration (INM), which describes dynamic movements of nuclei within the elongated cell bodies. We provide an overview of cytoskeletal components underlying INM in different systems, discuss current understanding of its kinetics and timing, and evaluate how conflicting results could be explained through developmental and evolutionary considerations.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	0962-8924 1879-3088 1879-3088
DOI:	10.1016/j.tcb.2012.11.001