Wearable and Implantable Intraocular Pressure Biosensors: Recent Progress and Future Prospects

Biosensors worn on or implanted in eyes have been garnering substantial attention since being proven to be an effective means to acquire critical biomarkers for monitoring the states of ophthalmic disease, diabetes. Among these disorders, glaucoma, the second leading cause of blindness globally, usu...

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Published inAdvanced science Vol. 8; no. 6; pp. 2002971 - n/a
Main Authors Yang, Cheng, Huang, Xinshuo, Li, Xiangling, Yang, Chengduan, Zhang, Tao, Wu, Qianni, liu, Dong, Lin, Haotian, Chen, Weirong, Hu, Ning, Xie, Xi
Format Journal Article
LanguageEnglish
Published Germany John Wiley & Sons, Inc 01.03.2021
John Wiley and Sons Inc
Wiley
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ISSN2198-3844
2198-3844
DOI10.1002/advs.202002971

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Summary:Biosensors worn on or implanted in eyes have been garnering substantial attention since being proven to be an effective means to acquire critical biomarkers for monitoring the states of ophthalmic disease, diabetes. Among these disorders, glaucoma, the second leading cause of blindness globally, usually results in irreversible blindness. Continuous intraocular pressure (IOP) monitoring is considered as an effective measure, which provides a comprehensive view of IOP changes that is beyond reach for the “snapshots” measurements by clinical tonometry. However, to satisfy the applications in ophthalmology, the development of IOP sensors are required to be prepared with biocompatible, miniature, transparent, wireless and battery‐free features, which are still challenging with many current fabrication processes. In this work, the recent advances in this field are reviewed by categorizing these devices into wearable and implantable IOP sensors. The materials and structures exploited for engineering these IOP devices are presented. Additionally, their working principle, performance, and the potential risk that materials and device architectures may pose to ocular tissue are discussed. This review should be valuable for preferable structure design, device fabrication, performance optimization, and reducing potential risk of these devices. It is significant for the development of future practical IOP sensors. Continuous intraocular pressure (IOP) monitoring, a promising measure for glaucoma's diagnosis and screening, provides a comprehensive view of IOP changes that is beyond reach for the “snapshots” measurements by clinical tonometry. This work summarizes materials, structures, working principles, performances, potential risks, and further applications of wearable and implantable IOP sensors. This discussion should be valuable for preferable IOP transducer's developments.
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ISSN:2198-3844
2198-3844
DOI:10.1002/advs.202002971