Quantification of the heterogeneous effect of static and dynamic perivascular structures on patient-specific local aortic wall mechanics using inverse finite element modeling and DENSE MRI

• Published in: Journal of biomechanics Vol. 138; p. 111119
• Main Authors: Bracamonte, Johane H., Wilson, John S., Soares, Joao S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.06.2022; Elsevier Limited
• Subjects: Adventitial loads; Algorithms; Aorta; Aortic arch; Aortic dissection; Boundary conditions; Coronary vessels; Data assimilation; Datasets; Deformation; DENSE MRI; Diastole; Displacement; Echoes; Elastic foundations; Energy; Finite element method; Image-based modeling; In vivo function; In vivo methods and tests; Inverse model; Load; Magnetic resonance imaging; Mathematical models; Mechanics (physics); Optimization algorithms; Periaortic interactions; Perivascular support; Stiffness; Systole; Tethering; Thorax; DENSE MRI; EFBC; Image-based modeling; Inverse model; DAA; IAA; Periaortic interactions; Tethering; LV; In vivo function; DTA; PA; Perivascular support; PC; LA; IVC; Aorta; Adventitial loads; Data assimilation; SSFP MRI
• ISSN: 0021-9290; 1873-2380; 1873-2380
• DOI: 10.1016/j.jbiomech.2022.111119

Recent studies have highlighted the relevance of perivascular interactions on aortic wall mechanics. Most of the approaches assume static perivascular structures; however, the beating heart dynamically displaces the neighboring aorta. We develop a model to account for the effect of periaortic interactions due to static and dynamic structures by prescribing a moving elastic foundation boundary condition (EFBC) embedded into an inverse finite element algorithm using in vivo displacements from 2D displacement encoding with stimulated echoes (DENSE) MRI as target data. We applied this method at three different locations of interest, the distal aortic arch (DAA), descending thoracic aorta (DTA), and infrarenal abdominal aorta (IAA) for a total of 27 cases in healthy humans. The model reproduces the target diastole-to-systole deformation and bulk displacement of the aortic wall with median displacement errors below 0.5mm. The EFBC showed good agreement with the location of anatomical features and was consistent among individuals of similar characteristics. Results show that an energy source acting on the adventitia is required to reproduce the displacements measured at the vicinity of the heart, but not at the abdomen. The average adventitial load as a percentage of the luminal pulse-pressure was found to increase with age and to decrease along the descending aorta, from 61% at the DAA to 37% at the DTA, and 30% at the IAA. This approach offers a patient-specific method to estimate in vivo adventitial loads and aortic wall stiffness, which can bring a better understanding of normal and pathological in vivo aortic function.