乳头状甲状腺癌术后复发的相关因素分析
为探讨乳头状甲状腺癌术后复发的影响因素,回顾分析自2011年1月1日至2013年3月30日就诊的符合纳入标准且临床资料完整的69例乳头状甲状腺癌术后患者,男18例,女51例,平均年龄为40.17±12.97岁。所有患者均行甲状腺彩超、甲状腺功能测定、甲状腺球蛋白及抗体测定,且于未停用左旋甲状腺素状态下。甲状腺功能测定检查3次或以上,利用SPSSl7.0对患者性别、年龄、肿瘤大小、手术方式、术后未停服左旋甲状腺素时促甲状腺激素(TSH)抑制程度、术后是否清甲治疗行单因素分析,多因素分析采用二分类Logistic回归分析术后复发的影响因素,绘制受试者工作特征曲线(ROC)曲线,用约登指数法确定术后...
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          | Published in | 同位素 Vol. 27; no. 1; pp. 22 - 27 | 
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| Main Author | |
| Format | Journal Article | 
| Language | Chinese | 
| Published | 
            中国医科大学附属第一医院核医学科,辽宁沈阳,110001
    
        2014
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| Subjects | |
| Online Access | Get full text | 
| ISSN | 1000-7512 | 
| DOI | 10.7538/tws.2014.27.01.0022 | 
Cover
| Summary: | 为探讨乳头状甲状腺癌术后复发的影响因素,回顾分析自2011年1月1日至2013年3月30日就诊的符合纳入标准且临床资料完整的69例乳头状甲状腺癌术后患者,男18例,女51例,平均年龄为40.17±12.97岁。所有患者均行甲状腺彩超、甲状腺功能测定、甲状腺球蛋白及抗体测定,且于未停用左旋甲状腺素状态下。甲状腺功能测定检查3次或以上,利用SPSSl7.0对患者性别、年龄、肿瘤大小、手术方式、术后未停服左旋甲状腺素时促甲状腺激素(TSH)抑制程度、术后是否清甲治疗行单因素分析,多因素分析采用二分类Logistic回归分析术后复发的影响因素,绘制受试者工作特征曲线(ROC)曲线,用约登指数法确定术后TSH值评价肿瘤复发的阈值。P〈O.05为差异有统计学意义。单因素分析结果表明,乳头状甲状腺癌术后复发与年龄、手术方式无明显相关性(分别为P=0.373、P=0.226),而与性别、肿瘤大小、术后TSH抑制程度、术后是否清甲治疗相关(分别为P=0.03l、P=0.004、P:0.00001、P=0.00005),男性、肿瘤越大、术后TSH值较高、术后未清甲治疗的复发率较高。Logistic回归分析表明,肿瘤大小、术后行TSH抑制治疗过程中TSH抑制程度及术后是否行清甲治疗是肿瘤复发的影响因素。用约登指数法,确定术后TSH抑制程度评价肿瘤复发的临界点为0.2253mU/L。肿瘤直径较大、术后TSH值较高、术后未行清甲治疗对肿瘤复发影响较大,为肿瘤复发的可能危险因素。 | 
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| Bibliography: | 11-2566/TL papillary thyroid cancer recurrence 1311 To investigate the factors that influences the recurrence of papillary thyroid canc- er, 69 patients with papillary thyroid cancer since January 1, 2011 to march 30, 2013 were analyzed respectively. They meet the inclusion criteria and complete clinical data, 18 males and 51 females, average age. 40. 17 ± 12. 97. Thyroid ultrasonography, thyroid function test, thyroglobulin and antibody measurement were performed on all patients and thyroid function were checked three or more times on the premise of continuously levothyroxine. Single factor analysis were performed using SPSS17.0 in these respects including patients' gender, age, tumor size, type of opetation, the inhibition degree of TSH with taking levo- thyroxine postoperative and whether to perform 131I thyroid remnant ablation. Binary Logis- tic regression analysis were used for studying recurrence factors in multivariate analysis. The ROC curve were drawn, and then determine the threshold of TSH to evalua  | 
| ISSN: | 1000-7512 | 
| DOI: | 10.7538/tws.2014.27.01.0022 |