Enhanced pain facilitation rather than impaired pain inhibition in burning mouth syndrome female patients

• Published in: Journal of headache and pain Vol. 23; no. 1; pp. 143 - 8
• Main Authors: Gremeau-Richard, Christelle, Pionchon, Paul, Mulliez, Aurélien, Dualé, Christian, Dallel, Radhouane
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 01.12.2022; Springer Nature B.V; SpringerOpen; BMC
• Subjects: Burning mouth syndrome; Case-Control Studies; Chronic Pain; Cryotherapy; Depression; Diffuse Noxious Inhibitory Control; Female; Heat; Humans; Hyperalgesia; Internal Medicine; Life Sciences; Medicine; Medicine & Public Health; Mental depression; Mouth; Neurological disorders; Neurology; Orofacial pain; Pain; Pain Measurement; Pain Medicine; Pain perception; Temporal summation; Thermal stimuli; Thermotherapy; Water; Temporal summation; Depression; Heat; Orofacial pain; Diffuse Noxious Inhibitory Control; Hyperalgesia
• ISSN: 1129-2369; 1129-2377; 1129-2377
• DOI: 10.1186/s10194-022-01516-7

Background Deficient endogenous pain modulation has been implicated in the development and exacerbation of chronic orofacial pain. To date, relatively little is known regarding the function of the endogenous pain modulation in patients with burning mouth syndrome (BMS). This case–control study investigated endogenous pain modulation in women with BMS. Methods Conditioned pain modulation (CPM) was assessed upon temporal summation (TSP) of thermal pain. Forty female subjects, 20 BMS patients and 20 age-matched control subjects, were included in a 2 session-protocol. Mechanical and thermal pain thresholds were measured on the forearm and hand. TSP was obtained using repetitive laser-evoked thermal stimuli applied on the non-dominant hand, at an intensity yielding to moderate pain. During TSP, CPM was produced by immersing the contralateral foot in a water bath at painful cold (8 °C) temperature. In control conditions, the foot was immersed in a water bath at not painful (30 °C) temperature. Results BMS was not associated with any impairment in thermal as well as mechanical extracephalic pain thresholds. TSP and CPM efficacy were similar in BMS patients and control subjects. However, BMS patients exhibited enhanced extracephalic heat hyperalgesia. Conclusion This study reveals that there is no impairment of endogenous pain inhibition mechanisms in BMS patients, but rather an increase in pain facilitation.