基于fALFF及ReHo法观察低氧暴露后飞行员静息态脑功能的变化

目的探讨静息态功能核磁共振成像（rs-fMRI）分数低频振幅（fALFF）和局域一致性（ReHo）方法在低氧暴露后飞行员静息态脑功能评价中的应用价值。方法 30名男性健康飞行员先后接受常压常氧、氧浓度为14.5%的常压低氧暴露,采用f ALFF及ReHo方法对受试者低氧暴露前后rs-f MRI数据进行对比分析,观察低氧暴露之后f ALFF及ReHo值发生变化的脑区。结果低氧暴露后,30名飞行员脉搏、血氧饱和度分别为64.0±10.6次/min、92.4%±3.9%,较暴露前（分别为71.4±10.9次/min、96.3%±1.3%）有所下降（P〈0.05）。静息态下,30名飞行员低氧暴露后f...

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Published inJie fang jun yi xue za zhi Vol. 40; no. 6; pp. 507 - 512
Main Author 刘洁 张挽时 钱龙 徐先荣 刘明熙 孟利民 王萍
Format Journal Article
LanguageChinese
Published Beijing People's Military Medical Press 2015
Subjects
Hypoxia
NMR
Nuclear magnetic resonance
Vitamin E
分数低频振幅
局域一致性
磁共振成像
缺氧
静息态脑功能
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ISSN0577-7402
DOI10.11855/j.issn.0577-7402.2015.06.18

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Summary:目的探讨静息态功能核磁共振成像（rs-fMRI）分数低频振幅（fALFF）和局域一致性（ReHo）方法在低氧暴露后飞行员静息态脑功能评价中的应用价值。方法 30名男性健康飞行员先后接受常压常氧、氧浓度为14.5%的常压低氧暴露,采用f ALFF及ReHo方法对受试者低氧暴露前后rs-f MRI数据进行对比分析,观察低氧暴露之后f ALFF及ReHo值发生变化的脑区。结果低氧暴露后,30名飞行员脉搏、血氧饱和度分别为64.0±10.6次/min、92.4%±3.9%,较暴露前（分别为71.4±10.9次/min、96.3%±1.3%）有所下降（P〈0.05）。静息态下,30名飞行员低氧暴露后f ALFF值降低的脑区包括双侧颞上回、右侧额上回,f ALFF值增高的脑区为左侧楔前叶,Re Ho值降低的脑区为右侧额上回（P〈0.05）,未发现Re Ho值增加的脑区。结论低氧暴露对静息态下某些脑区功能活动有明显影响,可能与认知功能变化有关。
Bibliography:Objective The objective of this study was to evaluate the basic changes in brain activity of pilots after hypoxic exposure with the use of resting-state functional magnetic resonance imaging（rs-f MRI） and regional homogeneity（Re Ho） method. Methods Thirty healthy male pilots were successively subjected to normal and hypoxic exposure（with an oxygen concentration of 14.5%）. Both the f ALFF and Re Ho methods were adopted to analyze the resting-state functional MRI data before and after hypoxic exposure of the subjects, the areas of the brain with f ALFF and Re Ho changes after hypoxic exposure were observed. ResultsAfter hypoxic exposure, the pulse was 64.0±10.6 beats/min, and the oxygen saturation was 92.4%±3.9% in these 30 pilots, and it was lower than those before exposure（71.4±10.9 beats/min, 96.3%±1.3%, P〈0.05）. Compared with the condition before hypoxic exposure, the f ALFF value was decreased in superior temporal gyri on both sides and the right superior frontal gyrus, and increase in the left precuneus,
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ISSN:0577-7402
DOI:10.11855/j.issn.0577-7402.2015.06.18