Association between polymorphisms in SLC15A1 and PLA2G16 genes and development of obesity in Chinese subjects

• Published in: Diabetes, metabolic syndrome and obesity Vol. 11; pp. 439 - 446
• Main Authors: Wang, Chun-Yang, Liu, Shu, Xie, Xiao-Nv, Luo, Zhi-Ying, Yang, Li, Tan, Zhi-Rong
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2018; Dove Medical Press
• Subjects: BMI; Body mass index; Chinese subjects; Disease susceptibility; Genes; Genetic aspects; Genetic polymorphisms; Genotyping; Han (Chinese people); Health aspects; Obesity; Original Research; Peptides; Phospholipases; Risk factors; Single nucleotide polymorphisms; SNPs; Type 2 diabetes; China; SNPs; Chinese subjects; obesity; genotyping; BMI
• ISSN: 1178-7007; 1178-7007
• DOI: 10.2147/DMSO.S161808

The small peptide transporter 1 (PepT-1) and adipose phospholipase A2 (AdPLA) play a key role in the development of obesity. However, there are no data assessing the impact of PepT-1 ( ) and AdPLA ( ) variants on obesity susceptibility. Therefore, we assessed the contribution of 9 single-nucleotide polymorphisms (SNPs) between these two genes on obesity susceptibility in Chinese subjects. A total of 611 participants were enrolled in the study, and 9 SNPs in the and genes were selected. Blood samples were collected for genotyping. Overweight and obesity were established by body mass index. Regression analyses were performed to test for any association of genetic polymorphisms with weight abnormality. The genotype frequencies ( =0.04 for rs9557029, =0.027 for rs1289389) were significantly different between obese or overweight subjects and healthy controls. However, no significant difference in allele was found between these three groups ( >0.05). Further logistic regression analyses adjusted for age and sex also failed to reveal significant associations between overweight, obesity, and the selected SNPs ( >0.05). Data indicate that the selected 9 SNPs in and genes were not related to obesity susceptibility in the Han Chinese population.