Psoriasis is associated with increased β-defensin genomic copy number

Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the β-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Com...

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Bibliographic Details
Published inNature genetics Vol. 40; no. 1; pp. 23 - 25
Main Authors Hollox, Edward J, Huffmeier, Ulrike, Zeeuwen, Patrick L J M, Palla, Raquel, Lascorz, Jesús, Rodijk-Olthuis, Diana, van de Kerkhof, Peter C M, Traupe, Heiko, de Jongh, Gys, Heijer, Martin den, Reis, André, Armour, John A L, Schalkwijk, Joost
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.01.2008
Nature Publishing Group
Subjects
Agriculture
Animal Genetics and Genomics
beta-Defensins - genetics
Biomedical and Life Sciences
Biomedicine
brief-communication
Cancer Research
Case-Control Studies
Cellular proteins
Chromosomes, Human, Pair 8
Diagnosis
Gene Dosage
Gene Function
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease
Human Genetics
Humans
Physiological aspects
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Psoriasis
Psoriasis - genetics
Risk factors
United States
Online AccessGet full text
ISSN1061-4036
1546-1718
1546-1718
DOI10.1038/ng.2007.48

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Summary:Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the β-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for β-defensin genes and risk of psoriasis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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We consider these authors to have contributed equally to the work
Author contributions
EH, AR, JS and JA conceived and coordinated the study. PvdK, HT, MH, PZ, DR-O, AR and JS collected and characterised the clinical samples. Copy number typing was performed by EH (MAPH/REDVR), RP, JA, JL, and UH (PRT). EH, JS, JA and GdeJ performed the statistical and typing quality analysis, with contributions from PZ, UH and MH. All authors contributed to the writing of the paper, with major input from EH, JS, AR and JA.
ISSN:1061-4036
1546-1718
1546-1718
DOI:10.1038/ng.2007.48