Carbopalladation Cascades Using Carbon-Carbon Triple Bonds: Recent Advances to Access Complex Scaffolds

• Published in: Chemistry : a European journal Vol. 22; no. 47; pp. 16718 - 16732
• Main Authors: Düfert, Alexander, Werz, Daniel B.
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 14.11.2016; Wiley Subscription Services, Inc
• Subjects: Alkenes; Alkynes; Carbon-carbon composites; carbopalladation; cascades; Chemical reactions; Chemistry; cross-coupling reactions; domino reactions; Heck reactions; Methodology; Natural products; Scaffolds; Transformations; cascades; Heck reactions; domino reactions; carbopalladation; cross-coupling reactions
• ISSN: 0947-6539; 1521-3765; 1521-3765
• DOI: 10.1002/chem.201603044

Alkynes are one of the most versatile functional groups as synthetic handles. They allow for a direct access to partially or fully substituted alkenes through difunctionalization reactions. A prominently utilized transformation for these sequences is the carbopalladation of alkynes, which can be followed by various termination steps such as aromatizations, dearomatizations, cross‐coupling reactions, or pericyclic processes, amongst others. This Minireview provides an overview of the recent literature published in the field of carbopalladation chemistry, both with a focus on methodology as well as its application in the syntheses of complex molecular scaffolds, natural products, and functional molecules. Complex chemistry! This Minireview provides an overview of the recent literature published in the field of carbopalladation chemistry, both with a focus on methodology as well as its application in the syntheses of complex molecular scaffolds, natural products, and functional molecules (see scheme).