Clinical, laboratory and ultrasonographic findings differentiating low‐grade intestinal T‐cell lymphoma from lymphoplasmacytic enteritis in cats

• Published in: Journal of veterinary internal medicine Vol. 35; no. 6; pp. 2685 - 2696
• Main Authors: Freiche, Valérie, Fages, Julien, Paulin, Mathieu Victor, Bruneau, Julie, Couronné, Lucile, German, Alexander J., Penninck, Dominique, Hermine, Olivier
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.11.2021; Wiley
• Subjects: Abdomen; alimentary lymphoma; Animals; Anorexia; Biochemistry; Biopsy; cat; Cat Diseases - diagnostic imaging; Cats; chronic enteropathy; Cohort Studies; enteritis; Enteritis - diagnostic imaging; Enteritis - veterinary; full‐thickness intestinal biopsies; histopathology; immunohistochemistry; inflammatory bowel disease; jejunum; Laboratories; lymph nodes; Lymphatic system; Lymphoma; Lymphoma, T-Cell - diagnostic imaging; Lymphoma, T-Cell - veterinary; Male; males; overeating; phenotype; Prospective Studies; SMALL ANIMAL; Small intestine; T-cell lymphoma; Ultrasonic imaging; ultrasonography; Veterinary colleges; Veterinary medicine; France; Paris France; full-thickness intestinal biopsies; alimentary lymphoma; ultrasonography; chronic enteropathy; inflammatory bowel disease; cat
• ISSN: 0891-6640; 1939-1676; 1939-1676
• DOI: 10.1111/jvim.16272

Background Low‐grade intestinal T‐cell lymphoma (LGITL) is the most common intestinal neoplasm in cats. Differentiating LGITL from lymphoplasmacytic enteritis (LPE) is challenging because clinical signs, laboratory results, diagnostic imaging findings, histology, immunohistochemistry, and clonality features may overlap. Objectives To evaluate possible discriminatory clinical, laboratory and ultrasonographic features to differentiate LGITL from LPE. Animals Twenty‐two cats diagnosed with LGITL and 22 cats with LPE based upon histology, immunohistochemistry, and lymphoid clonality. Methods Prospective, cohort study. Cats presented with clinical signs consistent with LGITL or LPE were enrolled prospectively. All data contributing to the diagnostic evaluation was recorded. Results A 3‐variable model (P < .001) consisting of male sex (P = .01), duration of clinical signs (P = .01), and polyphagia (P = .03) and a 2‐variable model (P < .001) including a rounded jejunal lymph node (P < .001) and ultrasonographic abdominal effusion (P = .04) were both helpful to differentiate LGITL from LPE. Conclusions and Clinical Importance Most clinical signs and laboratory results are similar between cats diagnosed with LGITL and LPE. However, male sex, a longer duration of clinical signs and polyphagia might help clinicians distinguish LGITL from LPE. On ultrasonography, a rounded jejunal lymph node, and the presence of (albeit small volume) abdominal effusion tended to be more prevalent in cats with LGITL. However, a definitive diagnosis requires comprehensive histopathologic and phenotypic assessment.