Absence of BAT-26 instability in gastric intestinal metaplasia

• Published in: Pathology International Vol. 51; no. 6; pp. 473 - 475
• Main Authors: Jin, Zhe, Tamura, Gen, Satoh, Michiko, Meguro, Toru, Miura, Takayuki, Hayashi, Masahiro, Osakabe, Mitsumasa, Ohmura, Kiyonari, Ogata, Shin-ya, Endoh, Yasushi, Motoyama, Teiichi
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Science Pty 01.06.2001; Wiley
• Subjects: BAT-26; gastric cancer; Genetic Markers; Humans; Intestinal Diseases; Intestinal Diseases - genetics; Intestinal Diseases - pathology; intestinal metaplasia; Intestinal Mucosa; Intestinal Mucosa - pathology; Metaplasia; Metaplasia - genetics; Metaplasia - pathology; microsatellite instability; Microsatellite Repeats; Microsatellite Repeats - genetics; Precancerous Conditions; Precancerous Conditions - genetics; Precancerous Conditions - pathology; Stomach Neoplasms; Stomach Neoplasms - genetics; Stomach Neoplasms - pathology
• ISSN: 1320-5463; 1440-1827
• DOI: 10.1046/j.1440-1827.2001.01220.x

BAT‐26 instability, a sensitive marker for the high‐frequency microsatellite instability (MSI‐H) phenotype, was analyzed in samples of gastric cancer and in adjacent intestinal metaplastic mucosae. Although all MSI‐H gastric cancer samples showed BAT‐26 instability, as assessed using 12 dinucleotide microsatellite markers, BAT‐26 instability was not found in the adjacent intestinal metaplastic mucosa in any of the samples.