Caveolin-1 and Atherosclerosis: Regulation of LDLs Fate in Endothelial Cells

• Published in: International journal of molecular sciences Vol. 24; no. 10; p. 8869
• Main Authors: Puddu, Alessandra, Montecucco, Fabrizio, Maggi, Davide
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.05.2023; MDPI
• Subjects: Atherosclerosis; Atherosclerosis - metabolism; Autophagy; B cells; Caveolae - metabolism; Caveolin 1 - metabolism; Cell Membrane - metabolism; Cellular signal transduction; Cholesterol; Development and progression; Endothelial Cells - metabolism; Endothelium; Homeostasis; Humans; Lipoproteins, LDL - metabolism; Localization; Nitric oxide; Proteins; Regulation; Review; Signal transduction; Smooth muscle; atherosclerosis; caveolin-1; LDL; caveolae
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms24108869

Caveolae are 50–100 nm cell surface plasma membrane invaginations observed in terminally differentiated cells. They are characterized by the presence of the protein marker caveolin-1. Caveolae and caveolin-1 are involved in regulating several signal transduction pathways and processes. It is well recognized that they have a central role as regulators of atherosclerosis. Caveolin-1 and caveolae are present in most of the cells involved in the development of atherosclerosis, including endothelial cells, macrophages, and smooth muscle cells, with evidence of either pro- or anti-atherogenic functions depending on the cell type examined. Here, we focused on the role of caveolin-1 in the regulation of the LDLs’ fate in endothelial cells.