Gynoid Fat Distribution and Adipocyte Trapping May Explain Virological Failure With Intramuscular Long-Acting Cabotegravir and Rilpivirine

Abstract Intramuscular long-acting antiretroviral drugs can improve adherence to lifelong antiretroviral treatment. Nevertheless, adipose tissue thickness and distribution play a critical role with injectable drugs. We describe a virological failure with cabotegravir and rilpivirine in a Black Afric...

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Bibliographic Details
Published inOpen forum infectious diseases Vol. 10; no. 5; p. ofad217
Main Authors de Malliard, Isabelle, Houist, Anne-Laure, Peytavin, Gilles, L’Yavanc, Thomas, Bouvier, Magali, Cappy, Pierre, Lelièvre, Jean-Daniel, Feredj, Elsa, Vindrios, William, Gallien, Sebastien, Melica, Giovanna
Format Journal Article
LanguageEnglish
Published US Oxford University Press 01.05.2023
Subjects
Brief Report
Life Sciences
intramuscular long-acting antiretroviral drugs
virological failure
HIV infection
adipocyte trapping
gynecoid fat distribution
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ISSN2328-8957
2328-8957
DOI10.1093/ofid/ofad217

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Summary:Abstract Intramuscular long-acting antiretroviral drugs can improve adherence to lifelong antiretroviral treatment. Nevertheless, adipose tissue thickness and distribution play a critical role with injectable drugs. We describe a virological failure with cabotegravir and rilpivirine in a Black African woman with human immunodeficiency virus type 1 with gynoid fat distribution (ie, adipose tissue prevailing in the pelvis and hip area) and body mass index <30 kg/m2.
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Potential conflicts of interest. All authors: No potential conflicts.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofad217