Mapping human genetic diversity in Asia

• Published in: Science (American Association for the Advancement of Science) Vol. 326; no. 5959; p. 1541
• Main Authors: Abdulla, Mahmood Ameen, Ahmed, Ikhlak, Assawamakin, Anunchai, Bhak, Jong, Brahmachari, Samir K, Calacal, Gayvelline C, Chaurasia, Amit, Chen, Chien-Hsiun, Chen, Jieming, Chen, Yuan-Tsong, Chu, Jiayou, Cutiongco-de la Paz, Eva Maria C, De Ungria, Maria Corazon A, Delfin, Frederick C, Edo, Juli, Fuchareon, Suthat, Ghang, Ho, Gojobori, Takashi, Han, Junsong, Ho, Sheng-Feng, Hoh, Boon Peng, Huang, Wei, Inoko, Hidetoshi, Jha, Pankaj, Jinam, Timothy A, Jin, Li, Jung, Jongsun, Kangwanpong, Daoroong, Kampuansai, Jatupol, Kennedy, Giulia C, Khurana, Preeti, Kim, Hyung-Lae, Kim, Kwangjoong, Kim, Sangsoo, Kim, Woo-Yeon, Kimm, Kuchan, Kimura, Ryosuke, Koike, Tomohiro, Kulawonganunchai, Supasak, Kumar, Vikrant, Lai, Poh San, Lee, Jong-Young, Lee, Sunghoon, Liu, Edison T, Majumder, Partha P, Mandapati, Kiran Kumar, Marzuki, Sangkot, Mitchell, Wayne, Mukerji, Mitali, Naritomi, Kenji, Ngamphiw, Chumpol, Niikawa, Norio, Nishida, Nao, Oh, Bermseok, Oh, Sangho, Ohashi, Jun, Oka, Akira, Ong, Rick, Padilla, Carmencita D, Palittapongarnpim, Prasit, Perdigon, Henry B, Phipps, Maude Elvira, Png, Eileen, Sakaki, Yoshiyuki, Salvador, Jazelyn M, Sandraling, Yuliana, Scaria, Vinod, Seielstad, Mark, Sidek, Mohd Ros, Sinha, Amit, Srikummool, Metawee, Sudoyo, Herawati, Sugano, Sumio, Suryadi, Helena, Suzuki, Yoshiyuki, Tabbada, Kristina A, Tan, Adrian, Tokunaga, Katsushi, Tongsima, Sissades, Villamor, Lilian P, Wang, Eric, Wang, Ying, Wang, Haifeng, Wu, Jer-Yuarn, Xiao, Huasheng, Xu, Shuhua, Yang, Jin Ok, Shugart, Yin Yao, Yoo, Hyang-Sook, Yuan, Wentao, Zhao, Guoping, Zilfalil, Bin Alwi
• Format: Journal Article
• Language: English
• Published: United States 11.12.2009
• Subjects: Algorithms; Asia; Asian Continental Ancestry Group - genetics; Asian Continental Ancestry Group - history; Bayes Theorem; Cluster Analysis; Emigration and Immigration - history; Ethnic Groups - genetics; Ethnic Groups - history; Gene Flow; Genotype; Geography; Haplotypes; History, Ancient; Humans; Language; Linguistics; Oligonucleotide Array Sequence Analysis; Phylogeny; Polymorphism, Single Nucleotide; Principal Component Analysis; Asia
• ISSN: 1095-9203; 0036-8075; 1095-9203
• DOI: 10.1126/science.1177074

Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.