Effects of Vigiis 101-LAB on a healthy population's gut microflora, peristalsis, immunity, and anti-oxidative capacity: A randomized, double-blind, placebo-controlled clinical study

• Published in: Heliyon Vol. 6; no. 9; p. e04979
• Main Authors: Chen, Chien-Li, Liou, Jyh-Ming, Lu, Tsong-Ming, Lin, Yi-Hsien, Wang, Chin-Kun, Pan, Tzu-Ming
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.09.2020; Elsevier
• Subjects: Anti-oxidative capacity; antioxidant activity; Bifidobacterium; clinical trials; Evidence-based medicine; feces; fermentation; Food microbiology; Gut microflora; Immunity; immunoglobulin G; intestinal microorganisms; Lactobacillus; Lactobacillus paracasei subsp. paracasei NTU 101; Microbiology; Nutrition; peristalsis; placebos; Probiotics; Food microbiology; Probiotics; Microbiology; Nutrition; Lactobacillus paracasei subsp. paracasei NTU 101; Gut microflora; Anti-oxidative capacity; Evidence-based medicine; Immunity
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2020.e04979

Vigiis 101-LAB capsules are produced from the fermentation of Lactobacillus paracasei subsp. paracasei NTU 101. We tested effects of Vigiis 101-LAB capsules I or II (5 or 10 billion CFU/day, respectively) on gut microflora in clinical trial I, and on peristalsis, immunity, and anti-oxidative capacity in clinical trial II, during a 4-week randomized, double-blind, placebo-controlled, adaptive-design study. In trial I, 36 subjects were divided into capsule I and placebo groups. After 4 weeks, Bifidobacterium spp. and Lactobacillus spp. counts were significantly higher in the feces of treatment subjects, with increases of 4.01- and 4.25-fold, respectively. In trial II, 52 subjects were divided into capsule II and placebo groups. After 4 weeks, the treatment group was found to have improved motility, decreased food transit time, and significantly increased immunoglobulin G, immunoglobulin M, and antioxidant activity. Thus, daily administration of Vigiis 101 capsule II can improve peristalsis, immunity, and anti-oxidative capacity. Microbiology; Food microbiology; Nutrition; Evidence-based medicine; Gut microflora; Immunity; Anti-oxidative capacity; Lactobacillus paracasei subsp. paracasei NTU 101; Probiotics