Lactobacillus plantarum LPYC225 mixture partially modulates the vaginal bacterial community of Gardnerella vaginalis-infected bacterial vaginosis in mice

• Published in: Food science and biotechnology Vol. 33; no. 9; pp. 2233 - 2242
• Main Authors: Kim, Hyun Ju, Kim, Dong-Gu, Kang, Sa-Haeng, Choi, Hoonsung, Go, Se-Woong, Kim, Dong-Keun, Myung, Je-Hun, Park, Jeong-Hyang, Soh, Ju-Ryoun, Kim, Suk-Kyu, Hong, Sung Wook, Kang, Miran, Park, Eui-Seong, Park, Ilbum, Kang, Jongsoo, Kwon, Hyuk Ju, Jin, Jong-Sik
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.07.2024; Springer Nature B.V; 한국식품과학회
• Subjects: Bacteria; bacterial communities; Bacteroides vulgatus; Chemistry; Chemistry and Materials Science; Dysbacteriosis; dysbiosis; E coli; Enterobacter; Escherichia coli; Food Science; Gardnerella vaginalis; Inflammation; Interleukin 6; Lactic acid; Lactic acid bacteria; Lactobacilli; Lactobacillus plantarum; microbiome; Microbiomes; Mixtures; Nutrition; Research Article; Vagina; Vaginosis; 식품과학; Bacterial vaginosis; Vaginal bacterial community; Inflammation; Lactobacillus
• ISSN: 1226-7708; 2092-6456; 2092-6456
• DOI: 10.1007/s10068-024-01641-w

Bacterial vaginosis (BV) is defined as dysbiosis of the vaginal microbiome associated with the depletion of Lactobacilli and excessive growth of commensal or pathogenic bacteria. This study investigated the effects of lactic acid bacteria (LAB) mixture (LM; InoRexyne™) on the vaginal bacterial community of Gardnerella vaginalis ( G. vaginalis )-infected BV mice. Single LAB and LM exhibited antibacterial and anti-inflammatory effects by inhibiting G. vaginalis growth and pro-inflammatory markers in RAW 264.7 cells. Administering LM did not significantly alter the vaginal architecture or fecal short-chain fatty acids but did significantly inhibit the vaginal interleukin-6 levels in the high LM group compared to the GV group. LM administration decreased the relative abundances of Enterobacter, Escherichia coli , and Bacteroides vulgatus in vaginal flushing fluids compared to the GV group. LM partially alleviated BV by inhibiting G. vaginalis growth and modulating the vaginal bacterial community, providing new insights into its modulatory effects on the vaginal microbiome in BV.