12-Month Time in Tight Range Improvement with Advanced Hybrid-Closed Loop System in Adults with Type 1 Diabetes

• Published in: Diabetes therapy Vol. 15; no. 12; pp. 2557 - 2568
• Main Authors: Nigi, Laura, Simon Batzibal, Maria De Los Angeles, Cataldo, Dorica, Dotta, Francesco
• Format: Journal Article
• Language: English
• Published: Cheshire Springer Healthcare 01.12.2024; Springer; Springer Nature B.V
• Subjects: Adults; Automation; Blood sugar; Blood sugar monitoring; Brief Report; Cardiology; Care and treatment; Clinical trials; Closed loop systems; Dextrose; Diabetes; Diabetes therapy; Endocrinology; Glucose; Glucose monitoring; Health aspects; Infusion pumps; Insulin; Internal Medicine; Medicine; Medicine & Public Health; Metabolic disorders; Patient outcomes; Physiological aspects; Technology application; Type 1 diabetes; Italy; Continuous glucose monitoring metrics; Advanced hybrid closed-loop systems; Time in tight range; Technology; Type 1 diabetes
• ISSN: 1869-6953; 1869-6961; 1869-6961
• DOI: 10.1007/s13300-024-01656-w

Introduction Time in tight range (TITR) is an emerging and valuable metric for assessing normoglycemia. The latest advancement in automated insulin delivery (AID) systems, the advanced hybrid closed-loop (AHCL) systems, are particularly noteworthy for managing type 1 diabetes (T1D) and enhancing glycemic control. Methods In a real-world clinical setting, we carried out a retrospective evaluation of TITR in 42 adult subjects with T1D using the AHCL Minimed™ 780G system over a 12-month period. Results Within just 14 days of activating the automatic mode, the AHCL Minimed™ 780G system showed rapid improvement in TITR, and in the other continuous glucose monitoring (CGM) metrics. This improvement persisted over 12 months, achieving the proposed 45–50% range for effective glycemic control. Conclusion The AHCL Minimed™ 780G system significantly enhances TITR, demonstrating continuous improvement throughout a 12-month follow-up period.