Update on recent advances in amyotrophic lateral sclerosis

• Published in: Journal of neurology Vol. 271; no. 7; pp. 4693 - 4723
• Main Authors: Riva, Nilo, Domi, Teuta, Pozzi, Laura, Lunetta, Christian, Schito, Paride, Spinelli, Edoardo Gioele, Cabras, Sara, Matteoni, Enrico, Consonni, Monica, Bella, Eleonora Dalla, Agosta, Federica, Filippi, Massimo, Calvo, Andrea, Quattrini, Angelo
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2024; Springer Nature B.V
• Subjects: Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - genetics; Amyotrophic Lateral Sclerosis - therapy; Animals; Clinical trials; Females; Gene therapy; Humans; Kinases; Life expectancy; Males; Medical imaging; Medical prognosis; Medicine; Medicine & Public Health; Molecular modelling; Motor neurone disease; Mutation; Neuroimaging; Neurological Update; Neurology; Neuroradiology; Neurosciences; Pathogenesis; Neuroimaging; Clinical management; ALS genetics; Pathogenesis; Motor neuron disease; Gene therapy; Assistive devices
• ISSN: 0340-5354; 1432-1459; 1432-1459
• DOI: 10.1007/s00415-024-12435-9

In the last few years, our understanding of disease molecular mechanisms underpinning ALS has advanced greatly, allowing the first steps in translating into clinical practice novel research findings, including gene therapy approaches. Similarly, the recent advent of assistive technologies has greatly improved the possibility of a more personalized approach to supportive and symptomatic care, in the context of an increasingly complex multidisciplinary line of actions, which remains the cornerstone of ALS management. Against this rapidly growing background, here we provide an comprehensive update on the most recent studies that have contributed towards our understanding of ALS pathogenesis, the latest results from clinical trials as well as the future directions for improving the clinical management of ALS patients.