Automatic detection of generalized paroxysmal fast activity in interictal EEG using time-frequency analysis

• Published in: Computers in biology and medicine Vol. 133; p. 104287
• Main Authors: Omidvarnia, Amir, Warren, Aaron E.L., Dalic, Linda J., Pedersen, Mangor, Jackson, Graeme
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.06.2021; Elsevier Limited
• Subjects: Automatic spike detection; Automation; Brain; Brain mapping; Channels; Children & youth; Cognition & reasoning; Cognitive ability; Convulsions & seizures; Decision making; Decomposition; EEG; Electrodes; Electroencephalography; Epilepsy; fMRI; Frequency dependence; Functional magnetic resonance imaging; General linear modelling; Generalized paroxysmal fast activity; Hypotheses; Inspection; Interictal epileptiform discharge; Internal Medicine; Lennox-gastaut syndrome; Morphology; Other; Patients; Seizures; Time-frequency analysis; Wavelet transforms; Generalized paroxysmal fast activity; fMRI; Time-frequency analysis; Interictal epileptiform discharge; EEG; Epilepsy; Lennox-gastaut syndrome; Automatic spike detection; General linear modelling
• ISSN: 0010-4825; 1879-0534; 1879-0534
• DOI: 10.1016/j.compbiomed.2021.104287

Markup of generalized interictal epileptiform discharges (IEDs) on EEG is an important step in the diagnosis and characterization of epilepsy. However, manual EEG markup is a time-consuming, subjective, and the specialized task where the human reviewer needs to visually inspect a large amount of data to facilitate accurate clinical decisions. In this study, we aimed to develop a framework for automated detection of generalized paroxysmal fast activity (GPFA), a generalized IED seen in scalp EEG recordings of patients with the severe epilepsy of Lennox-Gastaut syndrome (LGS). We studied 13 children with LGS who had GPFA events in their interictal EEG recordings. Time-frequency information derived from manually marked IEDs across multiple EEG channels was used to automatically detect similar events in each patient's interictal EEG. We validated true positives and false positives of the proposed spike detection approach using both standalone scalp EEG and simultaneous EEG-functional MRI (EEG-fMRI) recordings. GPFA events displayed a consistent low-high frequency arrangement in the time-frequency domain. This ‘bimodal’ spectral feature was most prominent over frontal EEG channels. Our automatic detection approach using this feature identified EEG events with similar time-frequency properties to the manually marked GPFAs. Brain maps of EEG-fMRI signal change during these automatically detected IEDs were comparable to the EEG-fMRI brain maps derived from manual IED markup. GPFA events have a characteristic bimodal time-frequency feature that can be automatically detected from scalp EEG recordings in patients with LGS. The validity of this time-frequency feature is demonstrated by EEG-fMRI analysis of automatically detected events, which recapitulates the brain maps we have previously shown to underlie generalized IEDs in LGS. This study provides a novel methodology that enables a fast, automated, and objective inspection of generalized IEDs in LGS. The proposed framework may be extendable to a wider range of epilepsy syndromes in which monitoring the burden of epileptic activity can aid clinical decision-making and faster assessment of treatment response and estimation of future seizure risk. •Generalized paroxysmal fast activity (GPFA) is common in Lennox-Gastaut syndrome.•GPFA represents a subject-specific bimodal pattern in the time-frequency domain.•We develop a technique for automatic detection of GPFA-like events in interictal EEG.•We use EEG-fMRI analysis to check the validity of automatically detected GPFA events.•Automatically detected and manually marked GPFA represent comparable brain maps.