Exosomes derived from mesenchymal stem cells in diabetes and diabetic complications

• Published in: Cell death & disease Vol. 15; no. 4; pp. 271 - 22
• Main Authors: Jiao, Yu-Rui, Chen, Kai-Xuan, Tang, Xiang, Tang, Yu-Long, Yang, Hai-Lin, Yin, Yu-Long, Li, Chang-Jun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.04.2024; Springer Nature B.V; Nature Publishing Group
• Subjects: 631/532/2074; 692/163/2743/137/138; Antibodies; Biochemistry; Biomedical and Life Sciences; Bone marrow; Cell Biology; Cell Communication; Cell Culture; Communication; Diabetes; Diabetes Complications - metabolism; Diabetes mellitus; Diabetes Mellitus - metabolism; Diabetic neuropathy; Endocrinology; Enzymes; Exosomes; Exosomes - metabolism; Hospitals; Humans; Hyperglycemia; Immunology; Life Sciences; Mesenchymal stem cells; Mesenchymal Stem Cells - metabolism; Metabolic disorders; Metabolism; Microenvironments; Proteins; Public health; Review; Review Article; Signal transduction; Stem cells; Stromal cells; Treatment Outcome
• ISSN: 2041-4889; 2041-4889
• DOI: 10.1038/s41419-024-06659-w

Diabetes, a group of metabolic disorders, constitutes an important global health problem. Diabetes and its complications place a heavy financial strain on both patients and the global healthcare establishment. The lack of effective treatments contributes to this pessimistic situation and negative outlook. Exosomes released from mesenchymal stromal cells (MSCs) have emerged as the most likely new breakthrough and advancement in treating of diabetes and diabetes‐associated complication due to its capacity of intercellular communication, modulating the local microenvironment, and regulating cellular processes. In the present review, we briefly outlined the properties of MSCs-derived exosomes, provided a thorough summary of their biological functions and potential uses in diabetes and its related complications.