Genomic epidemiology reveals transmission patterns and dynamics of SARS-CoV-2 in Aotearoa New Zealand

• Published in: Nature communications Vol. 11; no. 1; pp. 6351 - 7
• Main Authors: Geoghegan, Jemma L., Ren, Xiaoyun, Storey, Matthew, Hadfield, James, Jelley, Lauren, Jefferies, Sarah, Sherwood, Jill, Paine, Shevaun, Huang, Sue, Douglas, Jordan, Mendes, Fábio K., Sporle, Andrew, Baker, Michael G., Murdoch, David R., French, Nigel, Simpson, Colin R., Welch, David, Drummond, Alexei J., Holmes, Edward C., Duchêne, Sebastián, de Ligt, Joep
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.12.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 45/77; 631/181/757; 631/208/212/2304; 631/326/596/4130; 692/308/174; Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Coronaviruses; COVID-19; COVID-19 - epidemiology; COVID-19 - virology; Disease control; Disease transmission; Epidemiology; Female; Gene sequencing; Genome, Viral - genetics; Genomes; Genomics; Genomics - methods; Geography; Health promotion; Humanities and Social Sciences; Humans; Infant; Infant, Newborn; Male; Middle Aged; multidisciplinary; New Zealand - epidemiology; Pandemics; Phylogeny; Public health; SARS-CoV-2 - classification; SARS-CoV-2 - genetics; SARS-CoV-2 - physiology; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Viral diseases; Viruses; Whole genome sequencing; Whole Genome Sequencing - methods; Young Adult; New Zealand
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-020-20235-8

New Zealand, a geographically remote Pacific island with easily sealable borders, implemented a nationwide ‘lockdown’ of all non-essential services to curb the spread of COVID-19. Here, we generate 649 SARS-CoV-2 genome sequences from infected patients in New Zealand with samples collected during the ‘first wave’, representing 56% of all confirmed cases in this time period. Despite its remoteness, the viruses imported into New Zealand represented nearly all of the genomic diversity sequenced from the global virus population. These data helped to quantify the effectiveness of public health interventions. For example, the effective reproductive number, R e of New Zealand’s largest cluster decreased from 7 to 0.2 within the first week of lockdown. Similarly, only 19% of virus introductions into New Zealand resulted in ongoing transmission of more than one additional case. Overall, these results demonstrate the utility of genomic pathogen surveillance to inform public health and disease mitigation. New Zealand implemented stringent COVID-19 control measures early after identification of its first case. Here, the authors perform whole genome sequencing of samples taken until 22 May 2020 and find high viral diversity indicative of multiple separate introductions and limited community transmission.