Brain–computer interface-triggered functional electrical stimulation therapy for rehabilitation of reaching and grasping after spinal cord injury: a feasibility study

• Published in: Spinal cord series and cases Vol. 7; no. 1; p. 24
• Main Authors: Jovanovic, Lazar I., Kapadia, Naaz, Zivanovic, Vera, Rademeyer, Hope Jervis, Alavinia, Mohammad, McGillivray, Colleen, Kalsi-Ryan, Sukhvinder, Popovic, Milos R., Marquez-Chin, Cesar
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.03.2021; Nature Publishing Group
• Subjects: 692/308/409; 692/700/565/491; Anatomy; Biomedical and Life Sciences; Biomedicine; Brain-Computer Interfaces; Calibration; Electric Stimulation Therapy; Feasibility Studies; Hand Strength; Health care networks; Human Physiology; Humans; Neurochemistry; Neuropsychology; Neurosciences; Rehabilitation; Spinal cord injuries; Spinal Cord Injuries - therapy; Stroke
• ISSN: 2058-6124; 2058-6124
• DOI: 10.1038/s41394-020-00380-4

Study design Feasibility and preliminary clinical efficacy analysis in a single-arm interventional study. Objectives We developed a brain–computer interface-triggered functional electrical stimulation therapy (BCI-FEST) system for clinical application and conducted an interventional study to (1) assess its feasibility and (2) understand its potential clinical efficacy for the rehabilitation of reaching and grasping in individuals with sub-acute spinal cord injury (SCI). Setting Spinal cord injury rehabilitation hospital—Toronto Rehabilitation Institute—Lyndhurst Centre. Methods Five participants with sub-acute SCI completed between 12 and 40 1-hour sessions using BCI-FEST, with up to 5 sessions a week. We assessed feasibility by measuring participants’ compliance with treatment, the occurrence of adverse events, BCI sensitivity, and BCI setup duration. Clinical efficacy was assessed using Functional Independence Measure (FIM) and Spinal Cord Independence Measure (SCIM), as primary outcomes. In addition, we used two upper-limb function tests as secondary outcomes. Results On average, participants completed 29.8 sessions with no adverse events. Only one of the 149 sessions was affected by technical challenges. The BCI sensitivity ranged between 69.5 and 80.2%, and the mean BCI setup duration was ~11 min. In the primary outcomes, three out of five participants showed changes greater than the minimal clinically important differences (MCIDs). Additionally, the mean change in secondary outcome measures met the threshold for detecting MCID as well; four out of five participants achieved MCID. Conclusions The new BCI-FEST intervention is safe, feasible, and promising for the rehabilitation of reaching and grasping after SCI.