Exploring new roles for actin upon LTP induction in dendritic spines

Dendritic spines, small protrusions of the dendrites, enlarge upon LTP induction, linking morphological and functional properties. Although the role of actin in spine enlargement has been well studied, little is known about its relationship with mechanical membrane properties, such as membrane tensi...

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Published inScientific reports Vol. 11; no. 1; pp. 7072 - 11
Main Authors Bonilla-Quintana, Mayte, Wörgötter, Florentin
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 29.03.2021
Nature Publishing Group
Nature Portfolio
Subjects
631/114/116/2392
631/378/116/2392
631/378/2591
631/57/2266
Actin
Dendritic spines
Exocytosis
Filaments
Humanities and Social Sciences
Long-term potentiation
Membrane fusion
Membranes
multidisciplinary
Polymerization
Proteins
Science
Science (multidisciplinary)
Spine
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ISSN2045-2322
2045-2322
DOI10.1038/s41598-021-86367-z

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Summary:Dendritic spines, small protrusions of the dendrites, enlarge upon LTP induction, linking morphological and functional properties. Although the role of actin in spine enlargement has been well studied, little is known about its relationship with mechanical membrane properties, such as membrane tension, which is involved in many cell processes, like exocytosis. Here, we use a 3D model of the dendritic spine to investigate how polymerization of actin filaments can effectively elevate the membrane tension to trigger exocytosis in a domain close to the tip of the spine. Moreover, we show that the same pool of actin promotes full membrane fusion after exocytosis and spine stabilization.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-86367-z