Autopolymerizing acrylic repair resin containing low concentration of dimethylaminohexadecyl methacrylate to combat saliva-derived bacteria

• Published in: Journal of materials science. Materials in medicine Vol. 33; no. 6; pp. 49 - 13
• Main Authors: Zhou, Wen, Zhao, Hongyan, Li, Zhen, Huang, Xiaojing
• Format: Journal Article
• Language: English
• Published: New York Springer US 31.05.2022; Springer Nature B.V; Springer
• Subjects: Acrylic resins; Antiinfectives and antibacterials; Biocompatibility; Biofilms; Biomaterials; Biomaterials Synthesis and Characterization; Biomedical Engineering and Bioengineering; Biomedical materials; Cell walls; Ceramics; Chemistry and Materials Science; Complications; Composites; Flow cytometry; Glass; Materials Science; Mechanical properties; Metabolism; Microorganisms; Natural Materials; Polymer Sciences; Polymethyl methacrylate; Polymethylmethacrylate; Regenerative Medicine/Tissue Engineering; Resins; Saliva; Surfaces and Interfaces; Thin Films
• ISSN: 1573-4838; 0957-4530; 1573-4838
• DOI: 10.1007/s10856-022-06670-7

Biofilm accumulation on the polymethyl methacrylate (PMMA) restorations negatively affect the prognosis of the provisional restorations or the following treatment. This study developed a novel antibacterial PMMA resin containing low concentration of dimethylaminohexadecyl methacrylate (DMAHDM). Four resins were tested: (1) PMMA resin (Control), (2) 1.25% DMAHDM, (3) 2.5% DMAHDM, (4) 5% DMAHDM. Adding 1.25% DMAHDM into the PMMA resin did not influence the mechanical properties, degree of conversion, monomer releasing, and color stability of the specimens ( p  > 0.05). The incorporation of DMAHDM into PMMA resin could greatly prevent saliva-derived biofilms adhesion compared with the control group ( p  < 0.05). The metabolism level of saliva-derived biofilms on the 1.25%, 2.5%, and 5% DMAHDM resins were reduced by 20%, 54%, and 62%, respectively. And the mechanism of DMAHDM disturbing the integrity of bacterial cell walls was confirmed by flow cytometric analysis. Adding 1.25% and 2.5% DMAHDM did not compromise cytocompatibility of the modified resin ( p  > 0.05). Therefore, novel PMMA resin containing low concentration DMAHDM is promising as a future antimicrobial provisional restoration material for preventing microbial-induced complications in clinical settings. Graphical abstract