Evaluation of the Effect of Jawarish Amla Concoction on Controlling Stress in Women Candidate Intracytoplasmic Sperm Injection or In Vitro Fertilization: A Randomized Clinical Trial

• Published in: Advanced biomedical research Vol. 14; no. 1; p. 84
• Main Authors: Isakhani, Marzieh, Yousefsani, BahareSadat, Javedani Masroor, Mojgan, Bashiri, Maryam, Hashem-Dabaghian, Fataneh, Bioos, Soodabe, Taghavi Shirazi, Maryam, Kadkhodaei, Samira, Mahroozade, Somayye
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer - Medknow 01.08.2025; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Edition: 2
• Subjects: Clinical trials; Females; Fertility; Fertilization in vitro; Health services; In vitro fertilization; Infertility; Medical research; Medical science; mental health; Original Article; Patients; persian medicine; phyllanthus emblica; Reproductive technologies; Sperm; Spermatozoa; stress; Iran; stress; Persian medicine; Infertility; mental health; phyllanthus emblica
• ISSN: 2277-9175; 2277-9175
• DOI: 10.4103/abr.abr_249_24

Background: Infertility diagnostic investigations and treatment through assisted reproductive technology (ART) predispose infertile women to stress, while stress itself can severely affect the results of infertility treatment. This research aimed to investigate the effect of Jawarish Amla Concoction on controlling stress in female candidate intracytoplasmic sperm injection (ICSI) or in vitro fertilization (IVF). Materials and Methods: This randomized clinical trial was conducted between December 2022 and June 2023 at Shahid Akbarabadi Hospital, affiliated with the Iran University of Medical Sciences (IRCT20230411057883N1). A sample of 100 infertile female candidates for ICSI/IVF was randomly divided into two groups. Patients in the intervention group received one tablespoon of the Jawarish Amla Concoction (Phyllanthus emblica, Rosa damascene, and honey). The control group was only followed up on without any intervention. The stress level of the patients was measured based on Newton's Fertility Problem Inventory (FPI) at the beginning and end of the study, and its changes were compared in both groups. Results: Ninety women completed the study, and their data were analyzed. The mean FPI score in the intervention group was 160.76 ± 28.2 before the intervention and 153.39 ± 28.5 after the intervention, while it was respectively 141.07 ± 25.58 and 142.8 ± 31.05 in the control group. After four weeks, the percentage of changes in the FPI score was 16.67 ± 3.32% in the intervention group and 11.28 ± 1.18% in the control group (P = 0.045). No complications were observed. Conclusion: Consuming the Jawarish Amla Concoction for four weeks significantly reduced stress in female candidates for ICSI/IVF.