CD4 cell count and viral load count association and its joint risk factors among adult TB/HIV co-infected patients: a retrospective follow-up study

• Published in: BMC research notes Vol. 18; no. 1; pp. 377 - 11
• Main Authors: Muhie, Nurye Seid, Tegegne, Awoke Seyoum
• Format: Journal Article
• Language: English
• Published: London BioMed Central 01.09.2025; BioMed Central Ltd; BMC
• Subjects: Acquired immune deficiency syndrome; Adult; Adults; AIDS; Associations; Biomedical and Life Sciences; Biomedicine; CD4 antigen; CD4 cell; CD4 Lymphocyte Count; CD4 lymphocytes; Cells; Co-infected; Coinfection - immunology; Coinfection - virology; Confidentiality; Data analysis; Disease prevention; Female; Follow-Up Studies; Health aspects; Hematocrit; Hemoglobin; HIV; HIV infection; HIV Infections - blood; HIV Infections - complications; HIV Infections - immunology; HIV Infections - virology; Human immunodeficiency virus; Humans; Infections; Leukocytes; Life Sciences; Male; Medical research; Medicine, Experimental; Medicine/Public Health; Middle Aged; Monocytes; Patients; Physiological aspects; Research Note; Retrospective Studies; Ribonucleic acid; Risk Factors; RNA; Software; Tuberculosis; Tuberculosis - blood; Tuberculosis - complications; Tuberculosis - immunology; Tuberculosis - virology; Variables; Viral Load; Ethiopia; Adults; Co-infected; Associations; CD4 cell; Viral load
• ISSN: 1756-0500; 1756-0500
• DOI: 10.1186/s13104-025-07428-4

Objective The aim of this study was to determine CD4 cell count and viral load count association and its joint clinical risk factors among adult TB/HIV co-infected patients. The purpose of this research was leads to contribute improved planning and execution of screening programs, regular follow-ups, and prevention measures. Result The baseline variability for viral load ( ) was higher than CD4 cell (819.797). Furthermore, the correlation matrix (R) shows that the baseline subject-specific CD4 cell and viral load were negatively correlated (− 0. ). There was also a negative relationship between the subject-specific change CD4 cell and baseline viral load (- ), subject-specific baseline CD4 cell, and the patient-specific change of viral load (-0.6513), longitudinal trajectory (association of evolution) for the two random slopes -0.9413). Then, there was very strong negative relationship between subject-specific change CD4 cell and viral load over time. Visit time , white blood cell , good and fair ) adherence, hemoglobin ≥ 11 g/dl , baseline CD4 cell ≥ 200 cells/mm 3 , and baseline viral load < 10,000 copies/mL hematocrit and monocytes of patients were a joint determinates for viral load and CD4 cell, respectively.