Protective role of gut commensal microbes against intestinal infections

• Published in: The journal of microbiology Vol. 52; no. 12; pp. 983 - 989
• Main Authors: Yoon, My Young, Lee, Keehoon, Yoon, Sang Sun
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer-Verlag 01.12.2014; The Microbiological Society of Korea; Springer Nature B.V; 한국미생물학회
• Subjects: Animals; anti-infective properties; Bacteria; Bacteria - classification; Bacteria - immunology; Bacteria - metabolism; Bacterial diseases; Bacterial infections; Bacterial Infections - immunology; Biomedical and Life Sciences; ecosystems; Gastrointestinal tract; Gastrointestinal Tract - microbiology; Gastrointestinal Tract - physiopathology; Homeostasis; human health; Humans; Immune system; Immunity, Innate; Immunology; Infections; innate immunity; Intestinal Diseases - immunology; Intestinal Diseases - microbiology; intestinal microorganisms; intestines; Life Sciences; Microbiology; Microbiota; Microorganisms; Minireview; Pathogens; protective effect; Salmonella; Symbiosis - immunology; Symbiosis - physiology; 생물학; colonization resistance; enteropathogenic bacterial infection; gut microbiota
• ISSN: 1225-8873; 1976-3794; 1976-3794
• DOI: 10.1007/s12275-014-4655-2

The human gastrointestinal tract is colonized by multitudes of microorganisms that exert beneficial effects on human health. Mounting evidence suggests that intestinal microbiota contributes to host resistance against enteropathogenic bacterial infection. However, molecular details that account for such an important role has just begun to be understood. The commensal microbes in the intestine regulate gut homeostasis through activating the development of host innate immunity and producing molecules with antimicrobial activities that directly inhibit propagation of pathogenic bacteria. Understanding the protective roles of gut microbiota will provide a better insight into the molecular basis that underlies complicated interaction among host-pathogen-symbiont. In this review, we highlighted recent findings that help us broaden our knowledge of the intestinal ecosystem and thereby come up with a better strategy for combating enteropathogenic infection.