Inhaled nitric oxide therapy in neonates and children: reaching a European consensus

• Published in: Intensive care medicine Vol. 30; no. 3; pp. 372 - 380
• Main Authors: Macrae, Duncan J., Field, David, Mercier, Jean-Christophe, Møller, Jens, Stiris, Tom, Biban, Paolo, Cornick, Paul, Goldman, Allan, Göthberg, Sylvia, Gustafsson, Lars E., Hammer, Jürg, Lönnqvist, Per-Arne, Sanchez-Luna, Manuel, Sedin, Gunnar, Subhedar, Nim
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.03.2004; Berlin Springer Nature B.V
• Subjects: Administration; administration & dosage; Administration, Inhalation; Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Bronchodilator Agents; Bronchodilator Agents - administration & dosage; Bronchodilator Agents - pharmacology; Bronchodilator Agents - therapeutic use; Bronchodilator Agents/administration & dosage/pharmacology/therapeutic use; Child; Children; Dose-Response Relationship; Dose-Response Relationship, Drug; Drug; drug therapy; Human; Humans; Hypertension; Hypertension, Pulmonary - drug therapy; Infant; Infant, Newborn; Infant, Premature; Inhalation; Intensive care medicine; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; Neonates; Newborn; Nitric Oxide; Nitric Oxide - administration & dosage; Nitric Oxide - pharmacology; Nitric Oxide - therapeutic use; Nitric Oxide/administration & dosage/pharmacology/therapeutic use; Pediatrics; Persistent Fetal Circulation Syndrome; Persistent Fetal Circulation Syndrome - drug therapy; pharmacology; Premature; Pulmonary; Respiratory Distress Syndrome; Respiratory Distress Syndrome - drug therapy; therapeutic use; Treatment Outcome; Human; Intensive care; Extracorporeal membrane oxygenation; Respiratory disease; Cardiovascular disease; Pulmonary hypertension; Inhalation; Newborn; Treatment; Vasodilator; Nitric oxide; Inhaled nitric oxide; Oxygenation; Child; Persistent pulmonary hypertension of the newborn; Resuscitation; Pulmonary; Drug; Hypertension; Premature; Administration; Support; Adult/drug therapy; Infant; Respiratory Distress Syndrome; Dose-Response Relationship; Non-U.S. Gov't; Pulmonary/drug therapy
• ISSN: 0342-4642; 1432-1238
• DOI: 10.1007/s00134-003-2122-3

Inhaled nitric oxide (iNO) was first used in neonatal practice in 1992 and has subsequently been used extensively in the management of neonates and children with cardiorespiratory failure. This paper assesses evidence for the use of iNO in this population as presented to a consensus meeting jointly organised by the European Society of Paediatric and Neonatal Intensive Care, the European Society of Paediatric Research and the European Society of Neonatology. Consensus Guidelines on the Use of iNO in Neonates and Children were produced following discussion of the evidence at the consensus meeting.