Does the Child Behavior Checklist Juvenile Bipolar Disorder Phenotype Identify Bipolar Disorder?

• Published in: Biological psychiatry (1969) Vol. 62; no. 2; pp. 115 - 120
• Main Authors: Volk, Heather E., Todd, Richard D.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.07.2007; Elsevier Science
• Subjects: Adolescent; Adult and adolescent clinical studies; Attention Deficit Disorder with Hyperactivity - diagnosis; Attention Deficit Disorder with Hyperactivity - epidemiology; Attention Deficit Disorder with Hyperactivity - genetics; Biological and medical sciences; Bipolar Disorder - diagnosis; Bipolar Disorder - epidemiology; Bipolar Disorder - genetics; Bipolar disorders; Child; Child Behavior Checklist (CBCL); Cohort Studies; Comorbidity; Diagnostic and Statistical Manual of Mental Disorders; Diseases in Twins - diagnosis; Diseases in Twins - genetics; Dopamine Plasma Membrane Transport Proteins - genetics; Female; genetic; Genetic Predisposition to Disease - genetics; Genotype; Humans; juvenile bipolar disorder; Male; Medical sciences; Models, Genetic; Mood disorders; Personality Assessment; Personality Inventory - statistics & numerical data; Phenotype; Psychiatric Status Rating Scales; Psychiatry; Psychology, Adolescent; Psychology. Psychoanalysis. Psychiatry; Psychometrics; Psychopathology. Psychiatry; Receptors, Dopamine D4 - genetics; Suicide; twin; genetic; comorbidity; juvenile bipolar disorder; Child Behavior Checklist (CBCL); twin; suicide; Human; Mood disorder; Questionnaire; Psychometrics; Bipolar disorder; Suicide; Twin; Concomitant disease; Phenotype; Genetics; Behavior; Child
• ISSN: 0006-3223; 1873-2402
• DOI: 10.1016/j.biopsych.2006.05.036

A profile of Child Behavior Checklist(CBCL) T-scores ≥70 on the attention problems, aggression, and anxious/depressed subscales has been proposed to identify juvenile bipolar disorder(JBD). We tested this hypothesis in a population-based sample. Data for this analysis come from a birth-records-based twin sample having semi-structured interview and CBCL data ( N = 1,346). We compared prevalence of DSM-IV psychiatric disorders and suicidal behaviors in CBCL-JBD and non-CBCL-JBD subjects. Twin modeling assessed genetic and environmental contributions to CBCL-JBD. Associations with DRD4 and DAT1 were examined using chi-square tests. The prevalence of CBCL-JBD was 2.5%. No subjects with CBCL-JBD met criteria for bipolar or other mood disorders. CBCL-JBD subjects had more oppositional defiant disorder (ODD), conduct disorder(CD), and attention deficit hyperactivity disorder(ADHD). The CBCL-JBD profile was uncommon in these disorders. CBCL-JBD subjects more frequently endorsed suicidal behaviors. The CBCL-JBD profile was heritable and associated with the number of DAT1 9-repeat 3’ untranslated region alleles. The CBCL-JBD phenotype does not correspond with a semi-structured interview assessment of JBD. ADHD, CD, and ODD are common in children with CBCL-JBD but do not account for the profile. Increased suicidal behaviors indicate substantial impairment in CBCL-JBD subjects.