Acute changes in lipoprotein subclasses during exercise

• Published in: Metabolism, clinical and experimental Vol. 63; no. 1; pp. 61 - 68
• Main Authors: Søndergaard, Esben, Poulsen, Marianne K., Jensen, Michael D., Nielsen, Søren
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.01.2014; Elsevier
• Subjects: 1H NMR spectroscopy; Adult; Bicycling; Biological and medical sciences; Body Composition; Body Mass Index; Cardiovascular Diseases - prevention & control; Endocrinology & Metabolism; Exercise; Fasting; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; HDL; Humans; LDL; Lipoproteins - blood; Lipoproteins, HDL - blood; Lipoproteins, LDL - blood; Lipoproteins, VLDL - blood; Magnetic Resonance Spectroscopy; Male; Oxygen Consumption; Reference Values; Triglyceride; Triglycerides - blood; Vertebrates: anatomy and physiology, studies on body, several organs or systems; VLDL; FFA; VO2peak; 1H NMR; LPL; 1H NMR spectroscopy; Triglyceride; CVD; IDL; HDL; TG; DEXA; LDL; VLDL; BMI; Nuclear Magnetic Resonance; Cardiovascular disease; High density lipoprotein; Lipoprotein lipase; Body mass index; Dual X-ray absorptiometry; Intermediate density lipoprotein; Peak oxygen uptake; Low density lipoprotein; Free fatty acids; Very low-density lipoprotein; Physical exercise; Lipoprotein; Acute; Endocrinology; H NMR spectroscopy; H NMR
• ISSN: 0026-0495; 1532-8600; 1532-8600
• DOI: 10.1016/j.metabol.2013.08.011

Lipids are important substrates for oxidation in the basal fasting state and during exercise. Studies have demonstrated beneficial changes in lipoprotein subclass composition the day after an exercise bout. However, the acute effect of exercise on TG concentration and lipoprotein subclass composition remains unclear. Sixteen lean, healthy individuals (8 men and 8 women) were recruited (age 20–30years, BMI<25kg/m2). The subjects were studied during basal fasting conditions as well as during and after 90min of cycling at 50% of VO2peak. Lipoprotein subclass composition was measured with 1H NMR spectroscopy. During exercise, LDL and HDL particle concentration increased significantly (p<0.05) despite lower total TG concentration. In addition, exercise resulted in a shift towards smaller VLDL particles in men (p<0.05), but VLDL–TG concentration was unaltered. Acute exercise induces beneficial changes in lipoprotein subclass composition. These changes are similar to the effects of exercise training.