scTrends: A living review of commercial single-cell and spatial 'omic technologies

• Published in: Cell genomics Vol. 4; no. 12; p. 100723
• Main Authors: De Jonghe, Joachim, Opzoomer, James W, Vilas-Zornoza, Amaia, Nilges, Benedikt S, Crane, Peter, Vicari, Marco, Lee, Hower, Lara-Astiaso, David, Gross, Torsten, Morf, Jörg, Schneider, Kim, Cudini, Juliana, Ramos-Mucci, Lorenzo, Mooijman, Dylan, Tiklová, Katarína, Salas, Sergio Marco, Langseth, Christoffer Mattsson, Kashikar, Nachiket D, Schapiro, Denis, Lundeberg, Joakim, Nilsson, Mats, Shalek, Alex K, Cribbs, Adam P, Taylor-King, Jake P
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.12.2024; Elsevier
• Subjects: Genetics; High-Throughput Nucleotide Sequencing - methods; Humans; Review; Single-Cell Analysis - methods; Single-Cell Analysis - trends
• ISSN: 2666-979X; 2666-979X
• DOI: 10.1016/j.xgen.2024.100723

SummaryUnderstanding the rapidly evolving landscape of single-cell and spatial omic technologies is crucial for advancing biomedical research and drug development. We provide a living review of both mature and emerging commercial platforms, highlighting key methodologies and trends shaping the field. This review spans from foundational single-cell technologies such as microfluidics and plate-based methods to newer approaches like combinatorial indexing; on the spatial side, we consider next-generation sequencing and imaging-based spatial transcriptomics. Finally, we highlight emerging methodologies that may fundamentally expand the scope for data generation within pharmaceutical research, creating opportunities to discover and validate novel drug mechanisms. Overall, this review serves as a critical resource for navigating the commercialization and application of single-cell and spatial omic technologies in pharmaceutical and academic research.