Repressive effects of red bean, Phaseolus angularis, extracts on obesity of mouse induced with high-fat diet via downregulation of adipocyte differentiation and modulating lipid metabolism

• Published in: Food science and biotechnology Vol. 27; no. 6; pp. 1811 - 1821
• Main Authors: Park, Young Mi, Kim, Jee In, Seo, Dong Hyun, Seo, Joo Hee, Lim, Jae-Hwan, Lee, Jong Eun, Choi, Je-Yong, Seo, Eul-Won
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.12.2018; Springer Nature B.V; 한국식품과학회
• Subjects: Adipocytes; animal disease models; antioxidant activity; Beans; Blood; blood lipids; blood sampling; Chemistry; Chemistry and Materials Science; Cholesterol; Damage accumulation; Deoxyribonucleic acid; Diet; Differentiation; DNA; dose response; Fat metabolism; Food Science; Gene expression; genes; Hepatocytes; High fat diet; histology; Intestine; intestines; Lipid metabolism; Lipids; Metabolism; mice; Nutrition; Obesity; peroxisome proliferator-activated receptor gamma; red beans; Transcription factors; triacylglycerols; Vigna angularis var. angularis; 식품과학; Micro-CT; Obesity; Lipid metabolism; Adipocyte differentiation; Phaseolus angularis
• ISSN: 1226-7708; 2092-6456; 2092-6456
• DOI: 10.1007/s10068-018-0421-2

Obesity is generally caused by quantitative changes in adipocyte differentiation and fat metabolism. Only a few studies have been determined the effect of red beans extract on obesity and plasma cholesterol concentration. We have been studied the functional activities of red-bean extracts including anti-oxidative effect against DNA and cell damages. Histological study including micro CT analysis showed that the accumulation of fat in hepatocytes and intestines was significantly decreased in red bean extract treated group. In addition, plasma cholesterol and triglyceride levels were decreased in blood samples. In addition, it was confirmed that the red bean extract inhibited the expression of PPARγ, Fabp4 and RETN genes, which regulate total adipocyte differentiation and lipid metabolism. Red bean extract inhibits the expressions of transcription factors associated with adipocyte differentiation in a dose-dependent manner, thereby inhibiting fat accumulation and decreasing blood lipid levels in obese mice induced by high fat diet.