Effect of Kombucha on gut-microbiota in mouse having non-alcoholic fatty liver disease

• Published in: Food science and biotechnology Vol. 28; no. 1; pp. 261 - 267
• Main Authors: Jung, Youngmi, Kim, Inyoung, Mannaa, Mohamed, Kim, Jinnyun, Wang, Sihyung, Park, Inmyoung, Kim, Jieun, Seo, Young-Su
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.02.2019; Springer Nature B.V; 한국식품과학회
• Subjects: Black tea; Chemistry; Chemistry and Materials Science; Choline; Clostridium; Digestive system; Erysipelotrichia; Fatty liver; Fermentation; Food Science; Gastrointestinal tract; Intestinal microflora; intestinal microorganisms; Intestine; kombucha; Lactobacillus; Liver; Liver diseases; Metabolism; Methionine; Mice; Microbiota; Microorganisms; Mucispirillum; Nutrition; obesity; Rodents; Tea; 식품과학; Gut-microbiota; Non-alcoholic fatty liver disease; Liver protection; Kombucha tea
• ISSN: 1226-7708; 2092-6456; 2092-6456
• DOI: 10.1007/s10068-018-0433-y

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver disorders. Possible links have been recently found between the gut-microbiota and the host metabolism in development of NAFLD and obesity. Therefore, understanding the changes in intestinal microbiota during the progression of NAFLD, is important. In this study, the effect of Kombucha tea (KT), obtained by microbial fermentation of sugared black tea, was investigated on gut-microbiota during the progression of NAFLD. The results indicated a decrease in Erysipelotrichia class by treatment with KT in comparison to the methionine/choline-deficient (MCD)-fed db/db mice. Allobaculum , Turicibacter, and Clostridium genera, were only detected in MCD-fed db/db mice and were decreased after treatment with KT, whereas Lactobacillus was more abundant in MCD + KT-fed mice than in MCD only-fed mice and Mucispirillum , was found only in the MCD + KT-fed mice group. Our results demonstrated that the change of intestinal microbiota was influenced by KT intake, contributing to combat NAFLD.